Bibliographic Details
| Title: |
The maternal drug exposure birth cohort (DEBC) in China |
| Authors: |
Lu Li, Ke Wang, Meixian Wang, Jing Tao, Xiaohong Li, Zhen Liu, Nana Li, Xiaoxia Qiu, Hongwei Wei, Yuan Lin, Yuan He, Ying Deng, Hong Kang, Yuting Li, Ping Yu, Yanping Wang, Jun Zhu, Hanmin Liu |
| Source: |
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024) |
| Publisher Information: |
Nature Portfolio, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Abstract Drug exposure during pregnancy lacks global fetal safety data. The maternal drug exposure birth cohort (DEBC) study, a prospective longitudinal investigation, aims to explore the correlation of maternal drug exposure during pregnancy with pregnancy outcomes, and establish a human biospecimen biobank. Here we describe the process of establishing DEBC and show that the drug exposure rate in the first trimester of pregnant women in DEBC (n = 112,986) is 30.70%. Among the drugs used, dydrogesterone and progesterone have the highest exposure rates, which are 11.97% and 10.82%, respectively. The overall incidence of adverse pregnancy outcomes is 13.49%. Dydrogesterone exposure during the first trimester is correlated with higher incidences of stillbirth, preterm birth, low birth weight, and birth defects, along with a lower incidence of miscarriage/abortion. Due to the limitations of this cohort study, causative conclusions cannot be drawn. Further follow-up and in-depth data analysis are planned for future studies. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-024-49623-0 |
| Access URL: |
https://doaj.org/article/f543ad251d3647a381003ecac73a80c5 |
| Accession Number: |
edsdoj.f543ad251d3647a381003ecac73a80c5 |
| Database: |
Directory of Open Access Journals |
