Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity
| Title: | Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity |
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| Authors: | Isabel Baenas, Romina Miranda-Olivos, Roser Granero, Neus Solé-Morata, Isabel Sánchez, Antoni Pastor, Amparo del Pino-Gutiérrez, Ester Codina, Francisco J. Tinahones, José A. Fernández-Formoso, Núria Vilarrasa, Fernando Guerrero-Pérez, Rafael Lopez-Urdiales, Núria Virgili, Carles Soriano-Mas, Susana Jiménez-Murcia, Rafael de la Torre, Fernando Fernández-Aranda |
| Source: | European Psychiatry, Vol 66 (2023) |
| Publisher Information: | Cambridge University Press, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Psychiatry |
| Subject Terms: | 2-arachidonoylglycerol, anandamide, eating disorders, endocannabinoids, obesity, Psychiatry, RC435-571 |
| More Details: | Abstract Background Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) play a pivotal role in stimulating motivational behavior toward food and energy metabolism. Aberrant functioning of the endocannabinoid system has been observed in extreme weight conditions (EWCs), suggesting it may influence pathophysiology. Then, we aimed to analyze fasting AEA and 2-AG plasma concentrations among individuals with EWC (i.e., anorexia nervosa [AN] and obesity with and without eating disorders [EDs]) compared with healthy controls (HCs), and its association with clinical variables and body mass index (BMI). Methods The sample included 113 adult women. Fifty-seven belonged to the obesity group, 37 without EDs (OB-ED) and 20 with ED (OB+ED classified within the binge spectrum disorders), 27 individuals from the AN group, and 29 from the HC group. Peripheral blood samples, several clinical variables, and BMI were evaluated. Results Unlike 2-AG, AEA concentrations showed significant differences between groups (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0924-9338 1778-3585 |
| Relation: | https://www.cambridge.org/core/product/identifier/S0924933823024112/type/journal_article; https://doaj.org/toc/0924-9338; https://doaj.org/toc/1778-3585 |
| DOI: | 10.1192/j.eurpsy.2023.2411 |
| Access URL: | https://doaj.org/article/cf48579b93b7464abafe8a910f7e4e92 |
| Accession Number: | edsdoj.f48579b93b7464abafe8a910f7e4e92 |
| Database: | Directory of Open Access Journals |
| ISSN: | 09249338 17783585 |
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| DOI: | 10.1192/j.eurpsy.2023.2411 |
| Published in: | European Psychiatry |
| Language: | English |