Bibliographic Details
| Title: |
A specific gut microbiota signature is associated with an enhanced GLP-1 and GLP-2 secretion and improved metabolic control in patients with type 2 diabetes after metabolic Roux-en-Y gastric bypass |
| Authors: |
Laura Hernández-Montoliu, M-Mar Rodríguez-Peña, Rocío Puig, Brenno Astiarraga, Fernando Guerrero-Pérez, Nuria Virgili, Rafael López-Urdiales, Javier Osorio, Rosa Monseny, Claudio Lazzara, Lucía Sobrino, Manuel Pérez-Maraver, María Pérez-Prieto, Silvia Pellitero, Sonia Fernández-Veledo, Joan Vendrell, Nuria Vilarrasa |
| Source: |
Frontiers in Endocrinology, Vol 14 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: |
incretin, microbiota, type 2 diabetes remission, severe obesity, bariatric surgery, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: |
ObjectiveTo determine changes in incretins, systemic inflammation, intestinal permeability and microbiome modifications 12 months after metabolic RYGB (mRYGB) in patients with type 2 diabetes (T2D) and their relationship with metabolic improvement.Materials and methodsProspective single-center non-randomized controlled study, including patients with class II-III obesity and T2D undergoing mRYGB. At baseline and one year after surgery we performed body composition measurements, biochemical analysis, a meal tolerance test (MTT) and lipid test (LT) with determination of the area under the curve (AUC) for insulin, C-peptide, GLP-1, GLP-2, and fasting determinations of succinate, zonulin, IL-6 and study of gut microbiota.ResultsThirteen patients aged 52.6 ± 6.5 years, BMI 39.3 ± 1.4 kg/m2, HbA1c 7.62 ± 1.5% were evaluated. After mRYGB, zonulin decreased and an increase in AUC after MTT was observed for GLP-1 (pre 9371 ± 5973 vs post 15788 ± 8021 pM, P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-2392 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fendo.2023.1181744/full; https://doaj.org/toc/1664-2392 |
| DOI: |
10.3389/fendo.2023.1181744 |
| Access URL: |
https://doaj.org/article/f42fc369fb3544ab89c734e234d8bbff |
| Accession Number: |
edsdoj.f42fc369fb3544ab89c734e234d8bbff |
| Database: |
Directory of Open Access Journals |
