Bibliographic Details
| Title: |
A systematic review and meta-analysis of liver venous deprivation versus portal vein embolization before hepatectomy: future liver volume, postoperative outcomes, and oncological safety |
| Authors: |
Mohamed Ali Chaouch, Alessandro Mazzotta, Adriano Carneiro da Costa, Mohammad Iqbal Hussain, Amine Gouader, Bassem Krimi, Fabrizio Panaro, Boris Guiu, Olivier Soubrane, Hani Oweira |
| Source: |
Frontiers in Medicine, Vol 10 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Medicine (General) |
| Subject Terms: |
liver venous deprivation, portal embolization, liver failure, hepatectomy, surgery, remnant liver volume, Medicine (General), R5-920 |
| More Details: |
IntroductionThis systematic review aimed to compare liver venous deprivation (LVD) with portal vein embolization (PVE) in terms of future liver volume, postoperative outcomes, and oncological safety before major hepatectomy.MethodsWe conducted this systematic review and meta-analysis following the PRISMA guidelines 2020 and AMSTAR 2 guidelines. Comparative articles published before November 2022 were retained.ResultsThe literature search identified nine eligible comparative studies. They included 557 patients, 207 in the LVD group and 350 in the PVE group. This systematic review and meta-analysis concluded that LVD was associated with higher future liver remnant (FLR) volume after embolization, percentage of FLR hypertrophy, lower failure of resection due to low FLR, faster kinetic growth, higher day 5 prothrombin time, and higher 3 years’ disease-free survival. This study did not find any difference between the LVD and PVE groups in terms of complications related to embolization, FLR percentage of hypertrophy after embolization, failure of resection, 3-month mortality, overall morbidity, major complications, operative time, blood loss, bile leak, ascites, post hepatectomy liver failure, day 5 bilirubin level, hospital stay, and three years’ overall survival.ConclusionLVD is as feasible and safe as PVE with encouraging results making some selected patients more suitable for surgery, even with a small FLR.Systematic review registrationThe review protocol was registered in PROSPERO before conducting the study (CRD42021287628). |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2296-858X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fmed.2023.1334661/full; https://doaj.org/toc/2296-858X |
| DOI: |
10.3389/fmed.2023.1334661 |
| Access URL: |
https://doaj.org/article/f3f536a576cf4e739032863b9a56d0ad |
| Accession Number: |
edsdoj.f3f536a576cf4e739032863b9a56d0ad |
| Database: |
Directory of Open Access Journals |
