Dysregulation of neutrophil in sepsis: recent insights and advances

Bibliographic Details
Title:	Dysregulation of neutrophil in sepsis: recent insights and advances
Authors:	Ji Zhang, Yuwen Shao, Jingyi Wu, Jing Zhang, Xiangsheng Xiong, Jingjing Mao, Yunwei Wei, Changhong Miao, Hao Zhang
Source:	Cell Communication and Signaling, Vol 23, Iss 1, Pp 1-17 (2025)
Publisher Information:	BMC, 2025.
Publication Year:	2025
Collection:	LCC:Medicine LCC:Cytology
Subject Terms:	Sepsis, Neutrophil, Oxidative stress, Neutrophil extracellular traps, Organ injury, Medicine, Cytology, QH573-671
More Details:	Abstract Sepsis remains the leading cause of death in intensive care units. Despite newer antimicrobial and supportive therapies, specific treatments are still lacking. Neutrophils are pivotal components of the effector phase of the host immune defense against pathogens and play a crucial role in the control of infections under normal circumstances. In addition to its anti-infective effects, the dysregulation and overactivation of neutrophils may lead to severe inflammation or tissue damage and are potential mechanisms for poor prognosis in sepsis. This review focuses on recent advancements in the understanding of the functional status of neutrophils across various pathological stages of sepsis to explore the mechanisms by which neutrophils participate in sepsis progression and provide insights for the treatment of sepsis by targeting neutrophils.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1478-811X
Relation:	https://doaj.org/toc/1478-811X
DOI:	10.1186/s12964-025-02098-y
Access URL:	https://doaj.org/article/f3af2bbfd68349b6ae20a6507128b8d5
Accession Number:	edsdoj.f3af2bbfd68349b6ae20a6507128b8d5
Database:	Directory of Open Access Journals
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More Details
ISSN:	1478811X
DOI:	10.1186/s12964-025-02098-y
Published in:	Cell Communication and Signaling
Language:	English