Bibliographic Details
| Title: |
Targeting psychologic stress signaling pathways in Alzheimer’s disease |
| Authors: |
Hunter S. Futch, Cara L. Croft, Van Q. Truong, Eric G. Krause, Todd E. Golde |
| Source: |
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-10 (2017) |
| Publisher Information: |
BMC, 2017. |
| Publication Year: |
2017 |
| Collection: |
LCC:Neurology. Diseases of the nervous system
LCC:Geriatrics |
| Subject Terms: |
Alzheimer’s disease, Corticotropin-releasing hormone, Psychologic distress, Chronic stress, Neurodegeneration, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6 |
| More Details: |
Abstract Alzheimer’s Disease (AD) is the most prevalent progressive neurodegenerative disease; to date, no AD therapy has proven effective in delaying or preventing the disease course. In the search for novel therapeutic targets in AD, it has been shown that increased chronic psychologic stress is associated with AD risk. Subsequently, biologic pathways underlying psychologic stress have been identified and shown to be able to exacerbate AD relevant pathologies. In this review, we summarize the literature relevant to the association between psychologic stress and AD, focusing on studies investigating the effects of stress paradigms on transgenic mouse models of Amyloid-β (Aβ) and tau pathologies. In recent years, a substantial amount of research has been done investigating a key stress-response mediator, corticotropin-releasing hormone (CRH), and its interactions with AD relevant processes. We highlight attempts to target the CRH signaling pathway as a therapeutic intervention in these transgenic mouse models and discuss how targeting this pathway is a promising avenue for further investigation. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1750-1326 |
| Relation: |
http://link.springer.com/article/10.1186/s13024-017-0190-z; https://doaj.org/toc/1750-1326 |
| DOI: |
10.1186/s13024-017-0190-z |
| Access URL: |
https://doaj.org/article/eef378311fb24f55b85ca2f40a92c92d |
| Accession Number: |
edsdoj.f378311fb24f55b85ca2f40a92c92d |
| Database: |
Directory of Open Access Journals |
