Bibliographic Details
| Title: |
Case report: Bridging radiation therapy before chimeric antigen receptor T-cell therapy induces sustained remission in patients with relapsed/refractory double-expressor diffuse large B-cell lymphoma with localized compressive symptoms |
| Authors: |
Liying Yang, Mengdi Wu, Hao Yang, Xiaorong Sun, Lijie Xing, Dan Liu, Ligang Xing, Jinming Yu |
| Source: |
Frontiers in Immunology, Vol 15 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
lymphoma, double-expressor diffuse large B-cell lymphoma, chimeric antigen receptor T-cell immunotherapy, radiotherapy, bridging therapy, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
BackgroundHigh-risk double-expressor diffuse large B-cell lymphoma has an inferior prognosis following standard first-line therapy. After failure of second-line therapy, treatment options are limited if accompanied by localized compressive symptoms. Chimeric Antigen Receptor T cell (CAR-T) therapy preceded by bridging radiotherapy may be an effective emerging therapy.Case presentationWe report a 66-year-old female patient diagnosed with stage IV double-expressor diffuse large B-cell lymphoma. The patient achieved progressive disease after two cycles of rituximab, cyclophosphamide, liposomal doxorubicin, vincristine, and prednisone and continued to develop cervical lymph node recurrence after second-line therapy. The patient was infused with CAR-T cells after receiving focal bridging radiotherapy and remained in complete response more than 9 months after treatment. In addition, the patients did not experience serious adverse reactions related to radiotherapy as well as CAR-T cell therapy.ConclusionsIn this article, we describe a patient with double-expressor diffuse large B-cell lymphoma with localized compression symptoms after second-line treatment failure who benefited from CAR-T combined with focal bridging radiotherapy. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2024.1441404/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2024.1441404 |
| Access URL: |
https://doaj.org/article/f361748b4c4a46c0a963f0350bb8c9e8 |
| Accession Number: |
edsdoj.f361748b4c4a46c0a963f0350bb8c9e8 |
| Database: |
Directory of Open Access Journals |
