The impact of short-course total neoadjuvant therapy, long-course chemoradiotherapy, and upfront surgery on the technical difficulty of total mesorectal excision: an observational study with an intraoperative perspective
| Title: | The impact of short-course total neoadjuvant therapy, long-course chemoradiotherapy, and upfront surgery on the technical difficulty of total mesorectal excision: an observational study with an intraoperative perspective |
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| Authors: | Cheryl Xi-Zi Chong, Frederick H. Koh, Hui-Lin Tan, Sharmini Su Sivarajah, Jia-Lin Ng, Leonard Ming-Li Ho, Darius Kang-Lie Aw, Wen-Hsin Koo, Shuting Han, Si-Lin Koo, Connie Siew-Poh Yip, Fu-Qiang Wang, Fung-Joon Foo, Winson Jianhong Tan |
| Source: | Annals of Coloproctology, Vol 40, Iss 5, Pp 451-458 (2024) |
| Publisher Information: | Korean Society of Coloproctology, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the digestive system. Gastroenterology |
| Subject Terms: | rectal neoplasms, neoadjuvant therapy, surgical difficulty, minimally invasive surgical procedures, radiotherapy, Diseases of the digestive system. Gastroenterology, RC799-869 |
| More Details: | Purpose Total neoadjuvant therapy (TNT) is becoming the standard of care for locally advanced rectal cancer. However, surgery is deferred for months after completion, which may lead to fibrosis and increased surgical difficulty. The aim of this study was to assess whether TNT (TNT-RAPIDO) is associated with increased difficulty of total mesorectal excision (TME) compared with long-course chemoradiotherapy (LCRT) and upfront surgery. Methods Twelve laparoscopic videos of low anterior resection with TME for rectal cancer were prospectively collected from January 2020 to October 2021, with 4 videos in each arm. Seven colorectal surgeons assessed the videos independently, graded the difficulty of TME using a visual analog scale and attempted to identify which category the videos belonged to. Results The median age was 67 years, and 10 patients were male. The median interval to surgery from radiotherapy was 13 weeks in the LCRT group and 24 weeks in the TNT-RAPIDO group. There was no significant difference in the visual analog scale for difficulty in TME between the 3 groups (LCRT, 3.2; TNT-RAPIDO, 4.6; upfront, 4.1; P=0.12). A subgroup analysis showed similar difficulty between groups (LCRT 3.2 vs. TNT-RAPIDO 4.6, P=0.05; TNT-RAPIDO 4.6 vs. upfront 4.1, P=0.54). During video assessments, surgeons correctly identified the prior treatment modality in 42% of the cases. TNT-RAPIDO videos had the highest recognition rate (71%), significantly outperforming both LCRT (29%) and upfront surgery (25%, P=0.01). Conclusion TNT does not appear to increase the surgical difficulty of TME. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2287-9714 2287-9722 |
| Relation: | http://coloproctol.org/upload/pdf/ac-2023-00899-0128.pdf; https://doaj.org/toc/2287-9714; https://doaj.org/toc/2287-9722 |
| DOI: | 10.3393/ac.2023.00899.0128 |
| Access URL: | https://doaj.org/article/ef34bb6f2022473c83585fd29f803ad1 |
| Accession Number: | edsdoj.f34bb6f2022473c83585fd29f803ad1 |
| Database: | Directory of Open Access Journals |
| ISSN: | 22879714 22879722 |
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| DOI: | 10.3393/ac.2023.00899.0128 |
| Published in: | Annals of Coloproctology |
| Language: | English |