| Title: |
Relationship between heart failure and intestinal inflammation in infants with congenital heart disease |
| Authors: |
Qi-Liang Zhang, Xiu-Hua Chen, Si-Jia Zhou, Yu-Qing Lei, Qiang Chen, Hua Cao |
| Source: |
BMC Microbiology, Vol 24, Iss 1, Pp 1-7 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
Congenital heart disease, Heart failure, Intestinal microbiota, Intestinal inflammation, Infant, Microbiology, QR1-502 |
| More Details: |
Abstract Objective The association between heart failure (HF) and intestinal inflammation caused by a disturbed intestinal microbiota in infants with congenital heart disease (CHD) was investigated. Methods Twenty infants with HF and CHD who were admitted to our hospital between October 2021 and March 2022 were included in this study. Twenty age- and sex-matched infants without HF at our hospital were selected as the control group. Faecal samples were obtained from each participant and analysed by enzyme-linked immunoassay and 16 S rDNA sequencing to assess intestinal inflammatory factors and the microbiota. Results The levels of intestinal inflammatory factors, including IL-1β, IL-4, IL-6, IL-17 A and TNF-α, were greatly increased, while the levels of IL-10 were significantly decreased in the HF group compared to the control group (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2180 |
| Relation: |
https://doaj.org/toc/1471-2180 |
| DOI: |
10.1186/s12866-024-03229-0 |
| Access URL: |
https://doaj.org/article/f3450a01f63f4cca91d38fc4af0d4ff7 |
| Accession Number: |
edsdoj.f3450a01f63f4cca91d38fc4af0d4ff7 |
| Database: |
Directory of Open Access Journals |
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