Bibliographic Details
| Title: |
Effects of Sulforaphane and Chlorophyl a in a Western Diet-Induced Obesity Model |
| Authors: |
Tânia Martins, Ana Filipa Matos, Joana Soares, Rúben Leite, Maria João Pires, Maria de Lurdes Pinto, Maria João Neuparth, Sandra Mariza Monteiro, Ana Rita Sequeira, Luís Félix, Carlos Venâncio, Eduardo Rosa, Paula Alexandra Oliveira, Luís Miguel Antunes |
| Source: |
Obesities, Vol 3, Iss 4, Pp 265-286 (2023) |
| Publisher Information: |
MDPI AG, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Food processing and manufacture
LCC:Nutritional diseases. Deficiency diseases |
| Subject Terms: |
Chlorophyl a, C57BL/6J mice, diet-induced obesity, sulforaphane, Food processing and manufacture, TP368-456, Nutritional diseases. Deficiency diseases, RC620-627 |
| More Details: |
The global rise in obesity and its co-morbidities raises worldwide health, social and economic concerns, especially in developed countries. Compounds derived from natural sources are now in the focus of pharmacological therapies. In recent years, sulforaphane (SFN) has been the subject of studies due to its anti-cancer, anti-inflammatory, antioxidant and potential anti-obesity effects. Lately, some studies have also reported the anti-obesogenic potential of chlorophyll. In this study, we evaluated the anti-obesity effects of SFN and chlorophyll a (Chlo.a) in C57BL/6J mice fed with a Western diet, rich in sugar and fat. The study lasted 14 weeks, and for the last 4 weeks SFN (0.25 or 0.5 mg/kg/day) or Chlo.a (0.2 or 0.5 mg/kg/day) was administered orally. The results showed that supplementation with SFN or Chlo.a resulted in an increase in body temperature and a reduction in the size of adipocytes. However, the administration of SFN or Chlo.a for 4 weeks did not decrease the body weight gain or hepatic steatosis, and increased hepatic ROS counterbalancing with an increase in SOD activity. In conclusion, in the animal model used, treatment with SFN or Chlo.a did not show strong anti-obesity effects; however, slight improvements were observed with the supplementation of these compounds. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2673-4168 |
| Relation: |
https://www.mdpi.com/2673-4168/3/4/22; https://doaj.org/toc/2673-4168 |
| DOI: |
10.3390/obesities3040022 |
| Access URL: |
https://doaj.org/article/af2ebca32439459faaa75943b000243f |
| Accession Number: |
edsdoj.f2ebca32439459faaa75943b000243f |
| Database: |
Directory of Open Access Journals |
