Academic Journal
The Emergence of Carbapenem-Resistant Gram-Negative Bacteria in Mizoram, Northeast India
| Title: | The Emergence of Carbapenem-Resistant Gram-Negative Bacteria in Mizoram, Northeast India |
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| Authors: | Vanlalruati S. C. Ralte, Archana Loganathan, Prasanth Manohar, Christine Vanlalbiakdiki Sailo, Zothan Sanga, Lalremruata Ralte, John Zothanzama, Sebastian Leptihn, Ramesh Nachimuthu, Nachimuthu Senthil Kumar |
| Source: | Microbiology Research, Vol 13, Iss 3, Pp 342-349 (2022) |
| Publisher Information: | MDPI AG, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Microbiology |
| Subject Terms: | carbapenem-resistance, Gram-negative bacteria, Enterobacteriaceae, meropenem, antibiotic resistance, Microbiology, QR1-502 |
| More Details: | (Background) Numerous reports on carbapenem resistance in different parts of India have been published, yet there are insufficient studies on the prevalence of antibiotic resistance in the northeast region of the country. This study evaluated the emergence of carbapenem resistance in the clinical isolates collected in Mizoram. (Results) A total of 141 Gram-negative clinical isolates were collected from the two hospitals, including the Civil Hospital in Lunglei and the Synod Hospital in Aizawl. The isolates include Escherichia coli (n = 62, 43.9%), Klebsiella spp. (n = 43, 30.4%), Pseudomonas aeruginosa (n = 9, 6.3%), Serratia marcescens (n = 3, 2.1%), Proteus mirabilis (n = 2, 1.4%), Shigella spp. (n = 4, 2.8%), Enterobacter spp. (n = 6, 4.2%) and Acinetobacter spp. (n = 12, 8.5%). The isolates were found to be resistant to meropenem (11%), colistin (48%), tigecycline (25%) and cefotaxime (50%). A total of four E. coli and one Shigella sonnei encoded the blaOXA-48-like gene. The blaCTX-M-1 gene was detected in 13 isolates, of which eight were E. coli, two Shigella flexneri, and one isolates each of K. pneumoniae, K. oxytoca and Shigella sonnei, respectively. (Conclusion) Carbapenem-resistant Enterobacteriaceae are common among other parts of India, despite limited access to antibiotics, the emergence of resistance in the northeastern region is worrying. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 13030027 2036-7481 |
| Relation: | https://www.mdpi.com/2036-7481/13/3/27; https://doaj.org/toc/2036-7481 |
| DOI: | 10.3390/microbiolres13030027 |
| Access URL: | https://doaj.org/article/f2e3a25c8b334a989a1cea82ff156aea |
| Accession Number: | edsdoj.f2e3a25c8b334a989a1cea82ff156aea |
| Database: | Directory of Open Access Journals |
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| ISSN: | 13030027 20367481 |
|---|---|
| DOI: | 10.3390/microbiolres13030027 |
| Published in: | Microbiology Research |
| Language: | English |