Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men
| Title: | Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men |
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| Authors: | Charussri Leeyaphan, Jason J. Ong, Eric P.F. Chow, Fabian Y.S. Kong, Jane S. Hocking, Melanie Bissessor, Christopher K. Fairley, Marcus Y. Chen |
| Source: | Emerging Infectious Diseases, Vol 22, Iss 10, Pp 1778-1784 (2016) |
| Publisher Information: | Centers for Disease Control and Prevention, 2016. |
| Publication Year: | 2016 |
| Collection: | LCC:Medicine LCC:Infectious and parasitic diseases |
| Subject Terms: | rectal lymphogranuloma venereum, treatment, chlamydia, Chlamydia trachomatis, doxycycline, men who have sex with men, Medicine, Infectious and parasitic diseases, RC109-216 |
| More Details: | Rectal lymphogranuloma venereum (LGV) has reemerged as a sexually transmitted infection among men who have sex with men (MSM), particularly those who are HIV-positive. We undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal LGV in MSM. Nine studies were included: 4 prospective, 4 retrospective, and 1 combined retrospective and prospective. In total, 282 MSM with rectal LGV were included in the studies. All studies reported using nucleic acid amplification tests to assess microbial cure. Most patients (>80%) had symptomatic rectal infection. The fixed-effects pooled efficacy for doxycycline was 98.5% (95% CI 96.3%–100%, I2 = 0%; p = 0.993). Doxycycline at 100 mg twice daily for 21 days demonstrated a high microbial cure rate. These data support doxycycline at this dosage and duration as first-line therapy for rectal LGV in MSM. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1080-6040 1080-6059 |
| Relation: | https://wwwnc.cdc.gov/eid/article/22/10/16-0986_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059 |
| DOI: | 10.3201/eid2210.160986 |
| Access URL: | https://doaj.org/article/f2bde5bba22745e88f935de1e5e753ee |
| Accession Number: | edsdoj.f2bde5bba22745e88f935de1e5e753ee |
| Database: | Directory of Open Access Journals |
| ISSN: | 10806040 10806059 |
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| DOI: | 10.3201/eid2210.160986 |
| Published in: | Emerging Infectious Diseases |
| Language: | English |