Bibliographic Details
| Title: |
Neuroepithelial cell-transforming 1 promotes cardiac fibrosis via the Wnt/β-catenin signaling pathway |
| Authors: |
Tianyu Li, Xue Xiong, Yujing Wang, Yue Li, Yao Liu, Mingxiu Zhang, Chao Li, Tong Yu, Wei Cao, Shuangshuang Chen, Huizhen Zhang, Xiaona Wang, Lifang Lv, Yuhong Zhou, Haihai Liang, Xuelian Li, Hongli Shan |
| Source: |
iScience, Vol 26, Iss 10, Pp 107888- (2023) |
| Publisher Information: |
Elsevier, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Science |
| Subject Terms: |
Biological sciences, Biochemistry, Molecular biology, Cell biology, Science |
| More Details: |
Summary: This study found that the level of neuroepithelial cell-transforming gene 1 protein (NET1) was significantly increased in a mouse cardiac fibrosis model. Moreover, the expression level of NET1 was increased in cardiac fibrosis induced by TGF-β1, suggesting that NET1 was involved in the pathological process of cardiac fibrosis. Overexpression of NET1 promoted β-catenin expression in the nucleus and significantly increased the proliferation and migration of cardiac fibroblasts. NET1 may form a complex with β-catenin through GSK3β. Knockdown of β-catenin alleviated the effects of NET1 overexpression on collagen production and cell migration. In the heart of NET1 knockout mice, NET1 knockout can reduce the expression of β-catenin, α-SMA, and collagen content induced by MI. In conclusion, NET1 may regulate the activation of Wnt/β-catenin and TGF/Smads signaling pathway, promote collagen synthesis in fibroblasts, and participate in cardiac fibrosis. Thus, NET1 may be a potential therapeutic target in cardiac fibrosis. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2589-0042 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S258900422301965X; https://doaj.org/toc/2589-0042 |
| DOI: |
10.1016/j.isci.2023.107888 |
| Access URL: |
https://doaj.org/article/f288bb519999461d870559fb502d0734 |
| Accession Number: |
edsdoj.f288bb519999461d870559fb502d0734 |
| Database: |
Directory of Open Access Journals |
