Bibliographic Details
| Title: |
Omeprazole Induced Rapid Drug Reaction with Eosinophilia, Systemic Symptoms, and Cross-Reactivity in Delayed-Type Hypersensitivity Associated with Proton-Pump Inhibitors: A Case Report and Literature Review |
| Authors: |
Kanokkarn Pinyopornpanish, Kanokporn Pinyopornpanish, Kanokwan Pinyopornpanish, Juthipong Benjanuwattra, Putthapon Teepapan, Apinya Chungcharoenpanich, Wannada Laisuan |
| Source: |
Case Reports in Immunology, Vol 2024 (2024) |
| Publisher Information: |
Hindawi Limited, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
Immunologic diseases. Allergy, RC581-607 |
| More Details: |
Background. Omeprazole, a proton pump inhibitor (PPI), is a widely used and generally safe agent for treating acid-related gastrointestinal conditions. However, drug reaction with eosinophilia and systemic symptoms (DRESSs) syndrome has been reported. Objectives. To report a case of omeprazole-induced rapid DRESS syndrome and to review the literature. Methods. Descriptive analysis of one new case and a case series from literature review. Results. We report a case of 82-year-old woman presenting with rapid-onset of DRESS syndrome. The condition was initially suspected to be caused by antibiotic, but the definite diagnosis was eventually omeprazole-induced DRESS syndrome as suggested by the enzyme-linked immune absorbent spot (ELISpot) assay along with the clinical picture. Previous literatures regarding cases of PPI-induced DRESS syndrome were pooled for descriptive analysis. Among 21 PPI cases pooled, esomeprazole was the most commonly implicated PPI (52.4%), followed by pantoprazole (19.1%), and omeprazole along with lansoprazole (both 14.3%). The issue of cross-reactivities amongst PPIs remains uncertain. Nonetheless, in situations in which a PPIs are deemed necessary, a prudent approach could be considering a switch to an alternative agent with distinct chemical structure. Conclusion. PPI is commonly used safely as an agent for acid-related gastrointestinal conditions. However, PPI-induced rapid DRESS syndrome can occur, particularly with prior exposure history. ELISpot is an in vitro test, useful in identifying the culprit agent in patients with delayed-type hypersensitivity reaction. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2090-6617 |
| Relation: |
https://doaj.org/toc/2090-6617 |
| DOI: |
10.1155/2024/1317971 |
| Access URL: |
https://doaj.org/article/f282df7819db4f0fa79e419d4bfe0391 |
| Accession Number: |
edsdoj.f282df7819db4f0fa79e419d4bfe0391 |
| Database: |
Directory of Open Access Journals |
