Academic Journal
View in EDS
Linked Full Text

Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis

Bibliographic Details
Title: Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
Authors: Liping Deng, Ruotong Ren, Zunpeng Liu, Moshi Song, Jingyi Li, Zeming Wu, Xiaoqing Ren, Lina Fu, Wei Li, Weiqi Zhang, Pedro Guillen, Juan Carlos Izpisua Belmonte, Piu Chan, Jing Qu, Guang-Hui Liu
Source: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Publisher Information: Nature Portfolio, 2019.
Publication Year: 2019
Collection: LCC:Science
Subject Terms: Science
More Details: DGCR8 is a component of the canonical microprocessor complex for microRNA biogenesis. Here the authors implicate DGCR8 in heterochromatin maintenance and aging attenuation independent of its miRNA-processing activity through Lamin B1, KAP1 and HP1 interaction. DGCR8 overexpression can alleviate aging and senescence
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-019-10831-8
Access URL: https://doaj.org/article/ef27753ea31d478c8881938090f2b42a
Accession Number: edsdoj.f27753ea31d478c8881938090f2b42a
Database: Directory of Open Access Journals
FullText Links:
  – Type: other
    Url: https://resolver.ebsco.com:443/public/rma-ftfapi/ejs/direct?AccessToken=4F5692EF0A10253738FB&Show=Object
Text:
  Availability: 0
CustomLinks:
  – Url: https://login.libproxy.scu.edu/login?url=http://www.nature.com/openurl?genre=article&title=Nature%20Communications&volume=10&issue=1&spage=1
    Name: Nature Publishing
    Category: fullText
    Text: Full Text from Nature Publishing
    MouseOverText: Full Text from Nature Publishing
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=20411723&ISBN=&volume=10&issue=1&date=20190701&spage=1&pages=1-16&title=Nature Communications&atitle=Stabilizing%20heterochromatin%20by%20DGCR8%20alleviates%20senescence%20and%20osteoarthritis&aulast=Liping%20Deng&id=DOI:10.1038/s41467-019-10831-8
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
  – Url: https://doaj.org/article/ef27753ea31d478c8881938090f2b42a
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from DOAJ
    MouseOverText: View record from DOAJ
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.f27753ea31d478c8881938090f2b42a
RelevancyScore: 929
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 928.767700195313
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Liping+Deng%22">Liping Deng</searchLink><br /><searchLink fieldCode="AR" term="%22Ruotong+Ren%22">Ruotong Ren</searchLink><br /><searchLink fieldCode="AR" term="%22Zunpeng+Liu%22">Zunpeng Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Moshi+Song%22">Moshi Song</searchLink><br /><searchLink fieldCode="AR" term="%22Jingyi+Li%22">Jingyi Li</searchLink><br /><searchLink fieldCode="AR" term="%22Zeming+Wu%22">Zeming Wu</searchLink><br /><searchLink fieldCode="AR" term="%22Xiaoqing+Ren%22">Xiaoqing Ren</searchLink><br /><searchLink fieldCode="AR" term="%22Lina+Fu%22">Lina Fu</searchLink><br /><searchLink fieldCode="AR" term="%22Wei+Li%22">Wei Li</searchLink><br /><searchLink fieldCode="AR" term="%22Weiqi+Zhang%22">Weiqi Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Pedro+Guillen%22">Pedro Guillen</searchLink><br /><searchLink fieldCode="AR" term="%22Juan+Carlos+Izpisua+Belmonte%22">Juan Carlos Izpisua Belmonte</searchLink><br /><searchLink fieldCode="AR" term="%22Piu+Chan%22">Piu Chan</searchLink><br /><searchLink fieldCode="AR" term="%22Jing+Qu%22">Jing Qu</searchLink><br /><searchLink fieldCode="AR" term="%22Guang-Hui+Liu%22">Guang-Hui Liu</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Nature Portfolio, 2019.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2019
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Science
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Science%22">Science</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: DGCR8 is a component of the canonical microprocessor complex for microRNA biogenesis. Here the authors implicate DGCR8 in heterochromatin maintenance and aging attenuation independent of its miRNA-processing activity through Lamin B1, KAP1 and HP1 interaction. DGCR8 overexpression can alleviate aging and senescence
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 2041-1723
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: https://doaj.org/toc/2041-1723
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1038/s41467-019-10831-8
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/ef27753ea31d478c8881938090f2b42a" linkWindow="_blank">https://doaj.org/article/ef27753ea31d478c8881938090f2b42a</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.f27753ea31d478c8881938090f2b42a
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.f27753ea31d478c8881938090f2b42a
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-019-10831-8
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 16
        StartPage: 1
    Subjects:
      – SubjectFull: Science
        Type: general
    Titles:
      – TitleFull: Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Liping Deng
      – PersonEntity:
          Name:
            NameFull: Ruotong Ren
      – PersonEntity:
          Name:
            NameFull: Zunpeng Liu
      – PersonEntity:
          Name:
            NameFull: Moshi Song
      – PersonEntity:
          Name:
            NameFull: Jingyi Li
      – PersonEntity:
          Name:
            NameFull: Zeming Wu
      – PersonEntity:
          Name:
            NameFull: Xiaoqing Ren
      – PersonEntity:
          Name:
            NameFull: Lina Fu
      – PersonEntity:
          Name:
            NameFull: Wei Li
      – PersonEntity:
          Name:
            NameFull: Weiqi Zhang
      – PersonEntity:
          Name:
            NameFull: Pedro Guillen
      – PersonEntity:
          Name:
            NameFull: Juan Carlos Izpisua Belmonte
      – PersonEntity:
          Name:
            NameFull: Piu Chan
      – PersonEntity:
          Name:
            NameFull: Jing Qu
      – PersonEntity:
          Name:
            NameFull: Guang-Hui Liu
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Type: published
              Y: 2019
          Identifiers:
            – Type: issn-print
              Value: 20411723
          Numbering:
            – Type: volume
              Value: 10
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature Communications
              Type: main
ResultId 1