Bibliographic Details
| Title: |
Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis |
| Authors: |
Liping Deng, Ruotong Ren, Zunpeng Liu, Moshi Song, Jingyi Li, Zeming Wu, Xiaoqing Ren, Lina Fu, Wei Li, Weiqi Zhang, Pedro Guillen, Juan Carlos Izpisua Belmonte, Piu Chan, Jing Qu, Guang-Hui Liu |
| Source: |
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
| Publisher Information: |
Nature Portfolio, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
DGCR8 is a component of the canonical microprocessor complex for microRNA biogenesis. Here the authors implicate DGCR8 in heterochromatin maintenance and aging attenuation independent of its miRNA-processing activity through Lamin B1, KAP1 and HP1 interaction. DGCR8 overexpression can alleviate aging and senescence |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-019-10831-8 |
| Access URL: |
https://doaj.org/article/ef27753ea31d478c8881938090f2b42a |
| Accession Number: |
edsdoj.f27753ea31d478c8881938090f2b42a |
| Database: |
Directory of Open Access Journals |
