Bibliographic Details
| Title: |
Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications |
| Authors: |
Valeria Internò, Giacomo Triggiano, Pierluigi De Santis, Luigia Stefania Stucci, Marco Tucci, Camillo Porta |
| Source: |
Frontiers in Oncology, Vol 12 (2022) |
| Publisher Information: |
Frontiers Media S.A., 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
diffuse low-grade gliomas, prognostic molecular stratification, IDH-wt grade 2 astrocytoma, pTERT mutation, EGFR amplification, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
The identification of specific molecular aberrations guides the prognostic stratification and management of grade 2 astrocytomas. Mutations in isocitrate dehydrogenase (IDH) 1 and 2, found in the majority of adult diffuse low-grade glioma (DLGG), seem to relate to a favorable prognosis compared to IDH wild-type (IDH-wt) counterparts. Moreover, the IDH-wt group can develop additional molecular alterations worsening the prognosis, such as epidermal growth factor receptor amplification (EGFR-amp) and mutation of the promoter of telomerase reverse transcriptase (pTERT-mut). This review analyzes the prognostic impact and therapeutic implications of genetic alterations in adult LGG. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2234-943X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fonc.2022.866623/full; https://doaj.org/toc/2234-943X |
| DOI: |
10.3389/fonc.2022.866623 |
| Access URL: |
https://doaj.org/article/f25a001b23594a86b5e680c666d460b4 |
| Accession Number: |
edsdoj.f25a001b23594a86b5e680c666d460b4 |
| Database: |
Directory of Open Access Journals |
