Academic Journal

Association of Umbilical Cord Plasma Acid-labile Subunit of the Insulin-like Growth Factor Ternary Complex with Anthropometry in Term Newborns

Bibliographic Details
Title:	Association of Umbilical Cord Plasma Acid-labile Subunit of the Insulin-like Growth Factor Ternary Complex with Anthropometry in Term Newborns
Authors:	Yen-Ming Tseng, Yea-Shwu Hwang, Chin-Li Lu, Shio-Jean Lin, Wen-Hui Tsai
Source:	Pediatrics and Neonatology, Vol 55, Iss 2, Pp 139-144 (2014)
Publisher Information:	Elsevier, 2014.
Publication Year:	2014
Collection:	LCC:Pediatrics
Subject Terms:	acid-labile subunit, birth weight, insulin-like growth factor, neonate, Pediatrics, RJ1-570
More Details:	Birth size can affect neonatal morbidity and mortality. The insulin-like growth factor (IGF) system is the most important endocrine factor influencing fetal growth. In the circulation, IGFs (mostly IGF-I) are bound to IGF-binding protein 3 (IGFBP-3) and an acid-labile subunit (ALS) to form a ternary complex. The ALS protects IGFs from decay and facilitates their endocrine activity. However, the function of ALS in fetal growth has not yet been fully determined. Methods: Venous umbilical plasma samples were obtained from 98 term neonates and analyzed using enzyme-linked immunosorbent assays. The ALS, IGF-I, and IGFBP-3 umbilical cord plasma levels were analyzed for their association with anthropometric measurements of the neonates. Results: The ALS, IGF-I, and IGFBP-3 cord plasma levels were positively correlated with birth weight (r = 0.42, p
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1875-9572
Relation:	http://www.sciencedirect.com/science/article/pii/S1875957213001575; https://doaj.org/toc/1875-9572
DOI:	10.1016/j.pedneo.2013.09.002
Access URL:	https://doaj.org/article/f227c59394014d249c9ab9e0b5b667c5
Accession Number:	edsdoj.f227c59394014d249c9ab9e0b5b667c5
Database:	Directory of Open Access Journals

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