Bibliographic Details
| Title: |
Association of Umbilical Cord Plasma Acid-labile Subunit of the Insulin-like Growth Factor Ternary Complex with Anthropometry in Term Newborns |
| Authors: |
Yen-Ming Tseng, Yea-Shwu Hwang, Chin-Li Lu, Shio-Jean Lin, Wen-Hui Tsai |
| Source: |
Pediatrics and Neonatology, Vol 55, Iss 2, Pp 139-144 (2014) |
| Publisher Information: |
Elsevier, 2014. |
| Publication Year: |
2014 |
| Collection: |
LCC:Pediatrics |
| Subject Terms: |
acid-labile subunit, birth weight, insulin-like growth factor, neonate, Pediatrics, RJ1-570 |
| More Details: |
Birth size can affect neonatal morbidity and mortality. The insulin-like growth factor (IGF) system is the most important endocrine factor influencing fetal growth. In the circulation, IGFs (mostly IGF-I) are bound to IGF-binding protein 3 (IGFBP-3) and an acid-labile subunit (ALS) to form a ternary complex. The ALS protects IGFs from decay and facilitates their endocrine activity. However, the function of ALS in fetal growth has not yet been fully determined. Methods: Venous umbilical plasma samples were obtained from 98 term neonates and analyzed using enzyme-linked immunosorbent assays. The ALS, IGF-I, and IGFBP-3 umbilical cord plasma levels were analyzed for their association with anthropometric measurements of the neonates. Results: The ALS, IGF-I, and IGFBP-3 cord plasma levels were positively correlated with birth weight (r = 0.42, p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1875-9572 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1875957213001575; https://doaj.org/toc/1875-9572 |
| DOI: |
10.1016/j.pedneo.2013.09.002 |
| Access URL: |
https://doaj.org/article/f227c59394014d249c9ab9e0b5b667c5 |
| Accession Number: |
edsdoj.f227c59394014d249c9ab9e0b5b667c5 |
| Database: |
Directory of Open Access Journals |
