BMP signaling alters aquaporin-4 expression in the mouse cerebral cortex

Bibliographic Details
Title:	BMP signaling alters aquaporin-4 expression in the mouse cerebral cortex
Authors:	Kazuya Morita, Naoyuki Matsumoto, Kengo Saito, Toshihide Hamabe-Horiike, Keishi Mizuguchi, Yohei Shinmyo, Hiroshi Kawasaki
Source:	Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Publisher Information:	Nature Portfolio, 2021.
Publication Year:	2021
Collection:	LCC:Medicine LCC:Science
Subject Terms:	Medicine, Science
More Details:	Abstract Aquaporin-4 (AQP4) is a predominant water channel expressed in astrocytes in the mammalian brain. AQP4 is crucial for the regulation of homeostatic water movement across the blood–brain barrier (BBB). Although the molecular mechanisms regulating AQP4 levels in the cerebral cortex under pathological conditions have been intensively investigated, those under normal physiological conditions are not fully understood. Here we demonstrate that AQP4 is selectively expressed in astrocytes in the mouse cerebral cortex during development. BMP signaling was preferentially activated in AQP4-positive astrocytes. Furthermore, activation of BMP signaling by in utero electroporation markedly increased AQP4 levels in the cerebral cortex, and inhibition of BMP signaling strongly suppressed them. These results indicate that BMP signaling alters AQP4 levels in the mouse cerebral cortex during development.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	2045-2322
Relation:	https://doaj.org/toc/2045-2322
DOI:	10.1038/s41598-021-89997-5
Access URL:	https://doaj.org/article/cf1dda2aa83c475798dc28df94fd5519
Accession Number:	edsdoj.f1dda2aa83c475798dc28df94fd5519
Database:	Directory of Open Access Journals
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More Details
ISSN:	20452322
DOI:	10.1038/s41598-021-89997-5
Published in:	Scientific Reports
Language:	English