Bibliographic Details
| Title: |
Clinical Characteristics and Outcomes of Patients With Heart Failure With Reduced Ejection Fraction and Chronic Obstructive Pulmonary Disease: Insights From PARADIGM‐HF |
| Authors: |
Solmaz Ehteshami‐Afshar, Leanne Mooney, Pooja Dewan, Akshay S. Desai, Ninian N. Lang, Martin P. Lefkowitz, Mark C. Petrie, Adel R. Rizkala, Jean L. Rouleau, Scott D. Solomon, Karl Swedberg, Victor C. Shi, Michael R. Zile, Milton Packer, John J. V. McMurray, Pardeep S. Jhund, Nathaniel M. Hawkins |
| Source: |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 4 (2021) |
| Publisher Information: |
Wiley, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
chronic obstructive pulmonary disease, ejection fraction, heart failure, hospitalization, mortality, neprilysin, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
Background Chronic obstructive pulmonary disease (COPD) is a common comorbidity in heart failure with reduced ejection fraction, associated with undertreatment and worse outcomes. New treatments for heart failure with reduced ejection fraction may be particularly important in patients with concomitant COPD. Methods and Results We examined outcomes in 8399 patients with heart failure with reduced ejection fraction, according to COPD status, in the PARADIGM‐HF (Prospective Comparison of Angiotensin Receptor Blocker–Neprilysin Inhibitor With Angiotensin‐Converting Enzyme Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure) trial. Cox regression models were used to compare COPD versus non‐COPD subgroups and the effects of sacubitril/valsartan versus enalapril. Patients with COPD (n=1080, 12.9%) were older than patients without COPD (mean 67 versus 63 years; P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2047-9980 |
| Relation: |
https://doaj.org/toc/2047-9980 |
| DOI: |
10.1161/JAHA.120.019238 |
| Access URL: |
https://doaj.org/article/f1947c06aea54dc6810c12c87aac40a8 |
| Accession Number: |
edsdoj.f1947c06aea54dc6810c12c87aac40a8 |
| Database: |
Directory of Open Access Journals |
