TEffect of Single Embryo Blastomere Biopsy from Human Frozen Embryos on Assisted Reproductive Outcomes
| Title: | TEffect of Single Embryo Blastomere Biopsy from Human Frozen Embryos on Assisted Reproductive Outcomes |
|---|---|
| Authors: | Shahrzad Aghajani, Ali Salehzadeh, Fatemeh Ghasemian, Marziyeh Mehrafza, Ahmad Hosseini |
| Source: | Cell Journal, Vol 24, Iss 10, Pp 628-636 (2022) |
| Publisher Information: | Royan Institute (ACECR), Tehran, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | aneuploidy, biopsy, blastocyst, genetic testing, pregnancy outcome, Medicine, Science |
| More Details: | Objective: Preimplantation genetic testing for aneuploidies (PGT-A) is used to determine chromosomal normality and achieve a successful live birth in infertile couples. There is a possible correlation between chromosomal aneuploidy, embryo development and pregnancy rate. This study evaluated the influence of single blastomere biopsy (SBB) on embryo development and pregnancy rates during frozen embryo transfer (FET) and fresh cycles.Materials and Methods: This quasi-experimental study evaluated 115 intracytoplasmic sperm injection (ICSI) cycles, including 443 embryos (6-8 cells) with a grade A on day three, following PGT-A in the fresh or FET cycles from February 2018 to June 2020. In addition, the fresh cycles without PGT were included as a control group (n=166 embryos). SBB was done on day three and was grouped as FET-PGT (n=149) and the fresh-PGT (n=128).Results: There is a more aneuploidy rate in the FET-PGT group compared to the fresh-PGT cycle (36.60% vs. 20.38%, P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2228-5806 2228-5814 |
| Relation: | https://www.celljournal.org/article_253355_886abc9c69c5d219c1de07b65dee659f.pdf; https://doaj.org/toc/2228-5806; https://doaj.org/toc/2228-5814 |
| DOI: | 10.22074/cellj.2022.8328 |
| Access URL: | https://doaj.org/article/ef0f3bad5743498685e0915aa0620bd9 |
| Accession Number: | edsdoj.f0f3bad5743498685e0915aa0620bd9 |
| Database: | Directory of Open Access Journals |
| ISSN: | 22285806 22285814 |
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| DOI: | 10.22074/cellj.2022.8328 |
| Published in: | Cell Journal |
| Language: | English |