Elucidating Iron Metabolism through Molecular Imaging
| Title: | Elucidating Iron Metabolism through Molecular Imaging |
|---|---|
| Authors: | Feifei Liao, Wenwen Yang, Linzi Long, Ruotong Yu, Hua Qu, Yuxuan Peng, Jieming Lu, Chenghuan Ren, Yueqi Wang, Changgeng Fu |
| Source: | Current Issues in Molecular Biology, Vol 46, Iss 4, Pp 2798-2818 (2024) |
| Publisher Information: | MDPI AG, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Biology (General) |
| Subject Terms: | iron metabolism, molecular mechanism, molecular imaging technology, visualization, iron homeostasis, Biology (General), QH301-705.5 |
| More Details: | Iron is essential for many physiological processes, and the dysregulation of its metabolism is implicated in the pathogenesis of various diseases. Recent advances in iron metabolism research have revealed multiple complex pathways critical for maintaining iron homeostasis. Molecular imaging, an interdisciplinary imaging technique, has shown considerable promise in advancing research on iron metabolism. Here, we comprehensively review the multifaceted roles of iron at the cellular and systemic levels (along with the complex regulatory mechanisms of iron metabolism), elucidate appropriate imaging methods, and summarize their utility and fundamental principles in diagnosing and treating diseases related to iron metabolism. Utilizing molecular imaging technology to deeply understand the complexities of iron metabolism and its critical role in physiological and pathological processes offers new possibilities for early disease diagnosis, treatment monitoring, and the development of novel therapies. Despite technological limitations and the need to ensure the biological relevance and clinical applicability of imaging results, molecular imaging technology’s potential to reveal the iron metabolic process is unparalleled, providing new insights into the link between iron metabolism abnormalities and various diseases. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1467-3045 1467-3037 |
| Relation: | https://www.mdpi.com/1467-3045/46/4/175; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045 |
| DOI: | 10.3390/cimb46040175 |
| Access URL: | https://doaj.org/article/f0cc53c7bd7d4b7b9c4fa3f2e46aed29 |
| Accession Number: | edsdoj.f0cc53c7bd7d4b7b9c4fa3f2e46aed29 |
| Database: | Directory of Open Access Journals |
| ISSN: | 14673045 14673037 |
|---|---|
| DOI: | 10.3390/cimb46040175 |
| Published in: | Current Issues in Molecular Biology |
| Language: | English |