New seco-anthraquinone glucoside from the roots of Rumex crispus
| Title: | New seco-anthraquinone glucoside from the roots of Rumex crispus |
|---|---|
| Authors: | Yong-Xiang Li, Na Li, Jing-Juan Li, Man Zhang, Hong-Tao Zhu, Dong Wang, Ying-Jun Zhang |
| Source: | Natural Products and Bioprospecting, Vol 12, Iss 1, Pp 1-9 (2022) |
| Publisher Information: | SpringerOpen, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Botany |
| Subject Terms: | Polygonaceae, Rumex crispus L., Anthranoids, Anti-fungal activity, Botany, QK1-989 |
| More Details: | Abstract A new seco-anthraquinone, crispuside A (1), and three new 3,4-dihydronaphthalen-1(2H)-ones, napthalenones A-C (2–4), were isolated from the roots of Rumex crispus L., along with 10 known anthraquinones (6–14) and naphthalenone (5). Their structures were fully determined by extensive spectroscopic analyses, including ECD, and X-ray crystallography in case of compound 5, whose absolute configuration was determined for the first time. The isolates 1, 6–14 were evaluated for their anti-inflammatory and anti-fungal activity against three skin fungi, e.g., Epidermophyton floccosum, Trichophyton rubrum, and Microsporum gypseum. Most of the isolates showed weak anti-fungal and anti-inflammatory activity. Only compound 9 exhibited obvious anti-fungal activity against E. floccosum (MIC50 = 2.467 ± 0.03 μM) and M. gypseum (MIC50 = 4.673 ± 0.077 μM), while the MIC50 values of the positive control terbinafine were 1.287 ± 0.012 and 0.077 ± 0.00258 μM, respectively. The results indicated that simple emodin type anthraquinone is more potential against skin fungi than its oxyglucosyl, C-glucosyl and glycosylated seco analogues. Graphical Abstract |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2192-2195 2192-2209 |
| Relation: | https://doaj.org/toc/2192-2195; https://doaj.org/toc/2192-2209 |
| DOI: | 10.1007/s13659-022-00350-3 |
| Access URL: | https://doaj.org/article/af08f8e683634a2d838dfb7641a87804 |
| Accession Number: | edsdoj.f08f8e683634a2d838dfb7641a87804 |
| Database: | Directory of Open Access Journals |
| ISSN: | 21922195 21922209 |
|---|---|
| DOI: | 10.1007/s13659-022-00350-3 |
| Published in: | Natural Products and Bioprospecting |
| Language: | English |