Academic Journal
View in EDS
PDF Full Text

PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence.

Bibliographic Details
Title: PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence.
Authors: Jesús Gonzalo-Asensio, Serge Mostowy, Jose Harders-Westerveen, Kris Huygen, Rogelio Hernández-Pando, Jelle Thole, Marcel Behr, Brigitte Gicquel, Carlos Martín
Source: PLoS ONE, Vol 3, Iss 10, p e3496 (2008)
Publisher Information: Public Library of Science (PLoS), 2008.
Publication Year: 2008
Collection: LCC:Medicine
LCC:Science
Subject Terms: Medicine, Science
More Details: Inactivation of the transcriptional regulator PhoP results in Mycobacterium tuberculosis attenuation. Preclinical testing has shown that attenuated M. tuberculosis phoP mutants hold promise as safe and effective live vaccine candidates. We focused this study to decipher the virulence networks regulated by PhoP. A combined transcriptomic and proteomic analysis revealed that PhoP controls a variety of functions including: hypoxia response through DosR crosstalking, respiratory metabolism, secretion of the major T-cell antigen ESAT-6, stress response, synthesis of pathogenic lipids and the M. tuberculosis persistence through transcriptional regulation of the enzyme isocitrate lyase. We also demonstrate that the M. tuberculosis phoP mutant SO2 exhibits an antigenic capacity similar to that of the BCG vaccine. Finally, we provide evidence that the SO2 mutant persists better in mouse organs than BCG. Altogether, these findings indicate that PhoP orchestrates a variety of functions implicated in M. tuberculosis virulence and persistence, making phoP mutants promising vaccine candidates.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1932-6203
Relation: http://europepmc.org/articles/PMC2566814?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0003496
Access URL: https://doaj.org/article/acf078ffa7584179b0b1223916c2ab17
Accession Number: edsdoj.f078ffa7584179b0b1223916c2ab17
Database: Directory of Open Access Journals
FullText Links:
  – Type: pdflink
    Url: https://content.ebscohost.com/cds/retrieve?content=AQICAHjPtM4BHU3ZchRwgzYmadcigk49r9CVlbU7V5F6lgH7WwGZ95Dkw0i-swEO75do7s66AAAA4TCB3gYJKoZIhvcNAQcGoIHQMIHNAgEAMIHHBgkqhkiG9w0BBwEwHgYJYIZIAWUDBAEuMBEEDAx23WIQOgyq7O_RUgIBEICBmf_DWMm2a0nX9bkDMOhJK7a5vk90UmlX8kjkNNW3QCqov2flH9B3R5dnEUjuLgtxCntMizMlpZWVp9P7w_zguoNBhfuG4THa1EMWg6EEk3zYUP9wi4OyKGiEf9aMCDn7bpLHrXWrgS9DbamOzUWNK4na48nRXGLX6sMLfTfiV-g7SEY49FpkZ64z7oW8UwyQwLUJYERC7F2JkQ==
Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=19326203&ISBN=&volume=3&issue=10&date=20080101&spage=e3496&pages=&title=PLoS ONE&atitle=PhoP%3A%20a%20missing%20piece%20in%20the%20intricate%20puzzle%20of%20Mycobacterium%20tuberculosis%20virulence.&aulast=Jes%C3%BAs%20Gonzalo-Asensio&id=DOI:10.1371/journal.pone.0003496
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
  – Url: https://doaj.org/article/acf078ffa7584179b0b1223916c2ab17
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from DOAJ
    MouseOverText: View record from DOAJ
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.f078ffa7584179b0b1223916c2ab17
RelevancyScore: 839
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 838.664306640625
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Jesús+Gonzalo-Asensio%22">Jesús Gonzalo-Asensio</searchLink><br /><searchLink fieldCode="AR" term="%22Serge+Mostowy%22">Serge Mostowy</searchLink><br /><searchLink fieldCode="AR" term="%22Jose+Harders-Westerveen%22">Jose Harders-Westerveen</searchLink><br /><searchLink fieldCode="AR" term="%22Kris+Huygen%22">Kris Huygen</searchLink><br /><searchLink fieldCode="AR" term="%22Rogelio+Hernández-Pando%22">Rogelio Hernández-Pando</searchLink><br /><searchLink fieldCode="AR" term="%22Jelle+Thole%22">Jelle Thole</searchLink><br /><searchLink fieldCode="AR" term="%22Marcel+Behr%22">Marcel Behr</searchLink><br /><searchLink fieldCode="AR" term="%22Brigitte+Gicquel%22">Brigitte Gicquel</searchLink><br /><searchLink fieldCode="AR" term="%22Carlos+Martín%22">Carlos Martín</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: PLoS ONE, Vol 3, Iss 10, p e3496 (2008)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Public Library of Science (PLoS), 2008.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2008
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Medicine<br />LCC:Science
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Science%22">Science</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Inactivation of the transcriptional regulator PhoP results in Mycobacterium tuberculosis attenuation. Preclinical testing has shown that attenuated M. tuberculosis phoP mutants hold promise as safe and effective live vaccine candidates. We focused this study to decipher the virulence networks regulated by PhoP. A combined transcriptomic and proteomic analysis revealed that PhoP controls a variety of functions including: hypoxia response through DosR crosstalking, respiratory metabolism, secretion of the major T-cell antigen ESAT-6, stress response, synthesis of pathogenic lipids and the M. tuberculosis persistence through transcriptional regulation of the enzyme isocitrate lyase. We also demonstrate that the M. tuberculosis phoP mutant SO2 exhibits an antigenic capacity similar to that of the BCG vaccine. Finally, we provide evidence that the SO2 mutant persists better in mouse organs than BCG. Altogether, these findings indicate that PhoP orchestrates a variety of functions implicated in M. tuberculosis virulence and persistence, making phoP mutants promising vaccine candidates.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 1932-6203
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: http://europepmc.org/articles/PMC2566814?pdf=render; https://doaj.org/toc/1932-6203
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1371/journal.pone.0003496
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/acf078ffa7584179b0b1223916c2ab17" linkWindow="_blank">https://doaj.org/article/acf078ffa7584179b0b1223916c2ab17</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.f078ffa7584179b0b1223916c2ab17
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.f078ffa7584179b0b1223916c2ab17
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1371/journal.pone.0003496
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        StartPage: e3496
    Subjects:
      – SubjectFull: Medicine
        Type: general
      – SubjectFull: Science
        Type: general
    Titles:
      – TitleFull: PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Jesús Gonzalo-Asensio
      – PersonEntity:
          Name:
            NameFull: Serge Mostowy
      – PersonEntity:
          Name:
            NameFull: Jose Harders-Westerveen
      – PersonEntity:
          Name:
            NameFull: Kris Huygen
      – PersonEntity:
          Name:
            NameFull: Rogelio Hernández-Pando
      – PersonEntity:
          Name:
            NameFull: Jelle Thole
      – PersonEntity:
          Name:
            NameFull: Marcel Behr
      – PersonEntity:
          Name:
            NameFull: Brigitte Gicquel
      – PersonEntity:
          Name:
            NameFull: Carlos Martín
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2008
          Identifiers:
            – Type: issn-print
              Value: 19326203
          Numbering:
            – Type: volume
              Value: 3
            – Type: issue
              Value: 10
          Titles:
            – TitleFull: PLoS ONE
              Type: main
ResultId 1