| Title: |
RNA Editing-Dependent and -Independent Roles of Adenosine Deaminases Acting on RNA Proteins in Herpesvirus Infection—Hints on Another Layer of Complexity |
| Authors: |
Vlatka Ivanišević, Lidia Žilić, Marina Čunko, Hana Fadiga, Ivana Munitić, Igor Jurak |
| Source: |
Viruses, Vol 15, Iss 10, p 2007 (2023) |
| Publisher Information: |
MDPI AG, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
herpesvirus, ADAR, dsRNA, RNA editing, miRNA, latency, Microbiology, QR1-502 |
| More Details: |
The Adenosine Deaminases Acting on RNA (ADAR) catalyze the posttranscriptional deamination of adenosine residues to inosine in double-stranded RNAs (dsRNAs, A-to-I editing), preventing the overactivation of dsRNA sensor molecules and interferons. RNA editing is the cornerstone of innate immunity that distinguishes between self and non-self (virus), and it is essential for normal regulation of cellular homeostasis. Although much is already known about the role of ADAR proteins in RNA virus infection, the role of ADAR proteins in herpesvirus infection remains largely unexplored. In this review, we provide several lines of evidence from studies of different herpesviruses for another level of complexity in regulating the already intricate biphasic life cycle of herpesviruses. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1999-4915 |
| Relation: |
https://www.mdpi.com/1999-4915/15/10/2007; https://doaj.org/toc/1999-4915 |
| DOI: |
10.3390/v15102007 |
| Access URL: |
https://doaj.org/article/f06151de4c52411cb061822e57af1adc |
| Accession Number: |
edsdoj.f06151de4c52411cb061822e57af1adc |
| Database: |
Directory of Open Access Journals |
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