Bibliographic Details
| Title: |
Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy |
| Authors: |
Veronica Rendo, Ivaylo Stoimenov, André Mateus, Elin Sjöberg, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Adrian Ng, Casey OʼBrien, Marios Giannakis, Per Artursson, Peter Nygren, Ian Cheong, Tobias Sjöblom |
| Source: |
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020) |
| Publisher Information: |
Nature Portfolio, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Allelic losses occurring in cancer cells have been suggested as potential targets for therapy. Here, the authors show how recurring loss of heterozygosity of a drug metabolic gene in colorectal cancers can be exploited using a low molecular weight compound. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-020-15111-4 |
| Access URL: |
https://doaj.org/article/f0524ece03f240dd980cb46a0462a392 |
| Accession Number: |
edsdoj.f0524ece03f240dd980cb46a0462a392 |
| Database: |
Directory of Open Access Journals |
