Bibliographic Details
| Title: |
Research progress on the mechanism of angiogenesis in wound repair and regeneration |
| Authors: |
Zhuojun Shi, Chong Yao, Yujie Shui, Site Li, Hong Yan |
| Source: |
Frontiers in Physiology, Vol 14 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Physiology |
| Subject Terms: |
mechanisms of angiogenesis regulation, wound healing, regeneration, signal conduction, diseases associated with angiogenesis, capillary, Physiology, QP1-981 |
| More Details: |
Poor wound healing and pathological healing have been pressing issues in recent years, as they impact human quality of life and pose risks of long-term complications. The study of neovascularization has emerged as a prominent research focus to address these problems. During the process of repair and regeneration, the establishment of a new vascular system is an indispensable stage for complete healing. It provides favorable conditions for nutrient delivery, oxygen supply, and creates an inflammatory environment. Moreover, it is a key manifestation of the proliferative phase of wound healing, bridging the inflammatory and remodeling phases. These three stages are closely interconnected and inseparable. This paper comprehensively integrates the regulatory mechanisms of new blood vessel formation in wound healing, focusing on the proliferation and migration of endothelial cells and the release of angiogenesis-related factors under different healing outcomes. Additionally, the hidden link between the inflammatory environment and angiogenesis in wound healing is explored. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-042X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fphys.2023.1284981/full; https://doaj.org/toc/1664-042X |
| DOI: |
10.3389/fphys.2023.1284981 |
| Access URL: |
https://doaj.org/article/acaf050fda1c4b8aacc05c6a50da0620 |
| Accession Number: |
edsdoj.f050fda1c4b8aacc05c6a50da0620 |
| Database: |
Directory of Open Access Journals |
