Bibliographic Details
| Title: |
The potential of mononuclear cells as a predictive marker for the level of stem cells in autologous peripheral blood stem cell transplantation in Multiple Myeloma: A Review Article |
| Authors: |
Darshana Kottahachchi, Tharushika Deshani Hewapathirana, Thisali Chandula Perera, Shashikala Suresh |
| Source: |
Medical Laboratory Journal, Vol 18, Iss 2, Pp 11-15 (2024) |
| Publisher Information: |
Golestan University of Medical Sciences, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
multiple myeloma, mononuclear cells, stem cells, autologous transplantation, plasma cells, Medicine |
| More Details: |
Multiple myeloma (MM) is a plasma cell neoplasm that is characterized by the clonal proliferation of malignant plasma cells in the bone marrow. It is considered the second most common hematological malignancy which accounts for approximately 1% - 2% of all cancers and among 10% of hematological malignancies. Autologous peripheral blood stem cell Transplantation (PBSCT) is the best treatment for MM. Since the optimum harvested stem cell yield is a crucial factor for sufficient engraftment, the enumeration of Mononuclear cell (MNC) count in peripheral blood and harvested CD 34+ stem cell count can be considered as the best predictive markers for the best timing of apheresis which positively correlates with engraftment outcome of PBSCT. MNC count can be obtained using either a hematological analyzer or peripheral blood smear while flow cytometry is the advanced technology that can be used to enumerate CD 34+ stem cell count other than peripheral blood smear. The unavailability of a flow cytometer, the expensiveness of this method, and the lack of trained personnel regarding this new technology, especially in lower-middle-income countries cause disturbance in the enumeration of stem cells. In such a situation, this review describes the importance of establishing an association between peripheral blood MNCs and harvested CD 34+ cells. Furthermore, this association facilitates conducting effective PBSCT for MM patients even in the absence of a flow cytometer and eventually, it focuses on decentralizing the treatment of PBSCT. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2538-4449 |
| Relation: |
http://mlj.goums.ac.ir/article-1-1626-en.pdf; https://doaj.org/toc/2538-4449 |
| Access URL: |
https://doaj.org/article/f03f8cdcbe4c494494c42b8a79739f79 |
| Accession Number: |
edsdoj.f03f8cdcbe4c494494c42b8a79739f79 |
| Database: |
Directory of Open Access Journals |
