Bibliographic Details
| Title: |
How breast cancer therapies impact body image – real-world data from a prospective cohort study collecting patient-reported outcomes |
| Authors: |
Melissa Afshar-Bakshloo, Sarah Albers, Chiara Richter, Ottilia Berninger, Jens-Uwe Blohmer, Robert Roehle, Dorothee Speiser, Maria Margarete Karsten |
| Source: |
BMC Cancer, Vol 23, Iss 1, Pp 1-13 (2023) |
| Publisher Information: |
BMC, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
Body image, Real-world data, Breast cancer, Patient-reported outcomes, Breast-conserving surgery, Mastectomy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Abstract Background In breast cancer patients body image (BI) is a crucial aspect of quality of life (QoL). This study examined the postoperative impact of different surgical approaches on long-term BI analyzing real-world data to guide pre- and postoperative patient care and preserve QoL. Methods EORTC QLQ-BR23 BI scores were collected electronically in 325 breast cancer patients within routine clinical care for a duration of 41.5 months (11/17/2016 – 4/30/2020) at predefined time points preoperatively and repeatedly up to two years after breast-conserving surgery (BCS) (n = 212), mastectomy alone (M) (n = 27) or mastectomy with immediate breast reconstruction (MIBR) (n = 86). Higher scores indicated better BI. A linear mixed regression model was used to analyze the impact of BCS, M and MIBR, as well as non-surgical therapies on BI at treatment initiation and over time. Results BI scores deteriorated by 5 points (95%-confidence interval (CI) -8.94 to -1.57, p≈0.005) immediately after BCS, by 7 points (95%-CI -12.13 to -1.80, p≈0.008) after MIBR and by 19 points (95%-CI -27.34 to -10.34, p 0.05). At treatment initiation chemotherapy was associated with a 22-point decline (95%-CI -25.39 to -17.87, p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2407 |
| Relation: |
https://doaj.org/toc/1471-2407 |
| DOI: |
10.1186/s12885-023-11172-y |
| Access URL: |
https://doaj.org/article/f02f9a4ff9f644e286801af9987feb79 |
| Accession Number: |
edsdoj.f02f9a4ff9f644e286801af9987feb79 |
| Database: |
Directory of Open Access Journals |
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