Bibliographic Details
| Title: |
Changes in aqueous humor cytokines and metabolomics in contralateral eye after unilateral cataract surgery |
| Authors: |
Yang Li, Taiying Cheng, Sujun Zhou, Fayuan Li, Wenjun Guo, Mingbo Li, Taixiang Liu |
| Source: |
BMC Ophthalmology, Vol 25, Iss 1, Pp 1-21 (2025) |
| Publisher Information: |
BMC, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Ophthalmology |
| Subject Terms: |
Metabolomics, Untargeted metabolomics, Diabetic retinopathy, Cataract, Aqueous humor, Mass spectrometry, Ophthalmology, RE1-994 |
| More Details: |
Abstract Background For patients with bilateral age-related cataracts, sequential phacoemulsification and intraocular lens implantation is a common treatment. However, it remains unclear whether surgery on the first eye has an impact on the second eye, as current research results are inconsistent. This study will explore whether surgery on one eye affects the non-operated eye through aqueous humor cytokines and metabolomic analyses in the second eye. Methods A rabbit model of unilateral phacoemulsification and intraocular lens implantation was established. The experimental group consisted of 15 rabbits undergoing this procedure. Postoperatively, rabbits were divided into five subgroups (three rabbits per subgroup), and aqueous humor was collected from both the operated and non-operated eyes at 1 day, 3 days, 1 week, 2 weeks, and 3 weeks after surgery. Additionally, 5 rabbits were selected as a control group, from which aqueous humor was extracted. Levels of IL-1a, IL-1β, IL-2, IL-4, IL-6, IL-8, IFN-γ, TNF-α, MCP-1, and VEGF in the aqueous humor were compared. In the clinical study, preoperative aqueous humor samples were collected from 22 patients undergoing bilateral phacoemulsification and intraocular lens implantation. Among them, 11 patients were tested for the aforementioned 10 cytokines, while the other 11 patients underwent untargeted metabolomics research. Results In the animal experiment, levels of all 10 cytokines in the operated eyes were significantly higher compared to both the control and non-operated eyes groups (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2415 |
| Relation: |
https://doaj.org/toc/1471-2415 |
| DOI: |
10.1186/s12886-025-03961-9 |
| Access URL: |
https://doaj.org/article/bfd20986d4104d609613280f7e4be548 |
| Accession Number: |
edsdoj.bfd20986d4104d609613280f7e4be548 |
| Database: |
Directory of Open Access Journals |
