Bibliographic Details
| Title: |
Humoral Responses Elicited by SARS-CoV-2 mRNA Vaccine in People Living with HIV |
| Authors: |
Lorie Marchitto, Debashree Chatterjee, Shilei Ding, Gabrielle Gendron-Lepage, Alexandra Tauzin, Marianne Boutin, Mehdi Benlarbi, Halima Medjahed, Mohamed Sylla, Hélène Lanctôt, Madeleine Durand, Andrés Finzi, Cécile Tremblay |
| Source: |
Viruses, Vol 15, Iss 10, p 2004 (2023) |
| Publisher Information: |
MDPI AG, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
SARS-CoV-2, PLWH, humoral responses, antibody responses, ADCC, neutralization, Microbiology, QR1-502 |
| More Details: |
While mRNA SARS-CoV-2 vaccination elicits strong humoral responses in the general population, humoral responses in people living with HIV (PLWH) remain to be clarified. Here, we conducted a longitudinal study of vaccine immunogenicity elicited after two and three doses of mRNA SARS-CoV-2 vaccine in PLWH stratified by their CD4 count. We measured the capacity of the antibodies elicited by vaccination to bind the Spike glycoprotein of different variants of concern (VOCs). We also evaluated the Fc-mediated effector functions of these antibodies by measuring their ability to eliminate CEM.NKr cells stably expressing SARS-CoV-2 Spikes. Finally, we measured the relative capacity of the antibodies to neutralize authentic SARS-CoV-2 virus after the third dose of mRNA vaccine. We found that after two doses of SARS-CoV-2 mRNA vaccine, PLWH with a CD4 count < 250/mm3 had lower levels of anti-RBD IgG antibodies compared to PLWH with a CD4 count > 250/mm3 (p < 0.05). A third dose increased these levels and importantly, no major differences were observed in their capacity to mediate Fc-effector functions and neutralize authentic SARS-CoV-2. Overall, our work demonstrates the importance of mRNA vaccine boosting in immuno-compromised individuals presenting low levels of CD4. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1999-4915 |
| Relation: |
https://www.mdpi.com/1999-4915/15/10/2004; https://doaj.org/toc/1999-4915 |
| DOI: |
10.3390/v15102004 |
| Access URL: |
https://doaj.org/article/bfc8eeab61784140a7f286084d74af12 |
| Accession Number: |
edsdoj.bfc8eeab61784140a7f286084d74af12 |
| Database: |
Directory of Open Access Journals |
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