Bibliographic Details
| Title: |
The potential role of T-cell metabolism-related molecules in chronic neuropathic pain after nerve injury: a narrative review |
| Authors: |
Xiaoke Dou, Rui Chen, Juexi Yang, Maosha Dai, Junhao Long, Shujun Sun, Yun Lin |
| Source: |
Frontiers in Immunology, Vol 14 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
chronic neuropathic pain, T cell, energy metabolism, P2X7R, PKM2, adiponectin, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
Neuropathic pain is a common type of chronic pain, primarily caused by peripheral nerve injury. Different T-cell subtypes play various roles in neuropathic pain caused by peripheral nerve damage. Peripheral nerve damage can lead to co-infiltration of neurons and other inflammatory cells, thereby altering the cellular microenvironment and affecting cellular metabolism. By elaborating on the above, we first relate chronic pain to T-cell energy metabolism. Then we summarize the molecules that have affected T-cell energy metabolism in the past five years and divide them into two categories. The first category could play a role in neuropathic pain, and we explain their roles in T-cell function and chronic pain, respectively. The second category has not yet been involved in neuropathic pain, and we focus on how they affect T-cell function by influencing T-cell metabolism. By discussing the above content, this review provides a reference for studying the direct relationship between chronic pain and T-cell metabolism and searching for potential therapeutic targets for the treatment of chronic pain on the level of T-cell energy metabolism. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1107298/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2023.1107298 |
| Access URL: |
https://doaj.org/article/bfbca0d2cd2d4437beee8db85170918c |
| Accession Number: |
edsdoj.bfbca0d2cd2d4437beee8db85170918c |
| Database: |
Directory of Open Access Journals |
