P104 INFLUENCE OF AGE AND GENDER ON 24-HOUR VARIABILITY OF CENTRAL BLOOD PRESSURE: FINDINGS FROM THE INTERNATIONAL 24-HOUR AMBULATORY AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC)

Bibliographic Details
Title:	P104 INFLUENCE OF AGE AND GENDER ON 24-HOUR VARIABILITY OF CENTRAL BLOOD PRESSURE: FINDINGS FROM THE INTERNATIONAL 24-HOUR AMBULATORY AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC)
Authors:	Thomas Weber, Athanase Protogerou, Siegfried Wassertheurer, Cristina Giannatasio, Piotr Jankowski, Yan Li, Alessandro Maloberti, Barry McDonnell, Carmel McEniery, Maria Lorenza Muiesan, Janos Nemcsik, Anna Paini, Enrique Rodilla, Ian Wilkinson, Robert Zweiker, James Sharman
Source:	Artery Research, Vol 24 (2018)
Publisher Information:	BMC, 2018.
Publication Year:	2018
Collection:	LCC:Specialties of internal medicine LCC:Diseases of the circulatory (Cardiovascular) system
Subject Terms:	Specialties of internal medicine, RC581-951, Diseases of the circulatory (Cardiovascular) system, RC666-701
More Details:	Background: Conventional brachial cuff BP is known to vary according to age and gender, but the influence of these factors on 24-hour ambulatory central BP is unknown. We sought to determine this in a large healthy population from 11 centers in Europe and Asia. Methods: 24-hour ambulatory BP using a validated oscillometric device (Mobilograph, I.E.M, Stolberg, Germany) was performed in 1645 individuals free from antihypertensive drugs. Participants were categorized as young (Y: 13–39 years; M/F:219/112), middle-aged (MA: 40–66 years; M/F:545/553), and older (O: 67–104 years; M/F:86/130). Nighttime/daytime difference (N/D) was defined as nighttime (01.00–06.00) minus daytime (09.00–21.00) values / daytime values. Results: Averaged 24-hour brachial BP was 125/79 (Y), 128/83 (MA), and 127/77 (O) mmHg. N/D for brachial SBP was −10.3% (Y), −6.4% (MA), and −4.7% (O), but was significantly less pronounced for central SBP: −1% (Y), −3.1% (MA), and −1.9% (O). Men, compared to women, had higher brachial and central SBPs, mainly in younger participants. Brachial pulse pressure (PP) displayed limited and age-dependent circadian variations, whereas central PP was substantially higher at nighttime: N/D was 24% (Y), 9% (MA), and 5.9% (O). Brachial and central PPs were higher in men in the younger group, but higher in women in middle-aged and older groups. Conclusion: Both age and gender each have a significant influence on 24-hour variability of central BP, but is different than variability in brachial BP. These data have potential implications for refining hypertension diagnosis and management.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1876-4401
Relation:	https://www.atlantis-press.com/article/125930098/view; https://doaj.org/toc/1876-4401
DOI:	10.1016/j.artres.2018.10.157
Access URL:	https://doaj.org/article/cdbf9277cadc4aa4a0a7d6332e40bc95
Accession Number:	edsdoj.bf9277cadc4aa4a0a7d6332e40bc95
Database:	Directory of Open Access Journals

More Details
ISSN:	18764401
DOI:	10.1016/j.artres.2018.10.157
Published in:	Artery Research
Language:	English