The Influence of Nigella sativa on the Increase of IFN-γ and Quality of Life in Lung Cancer Patients Undergoing Chemotherapy
| Title: | The Influence of Nigella sativa on the Increase of IFN-γ and Quality of Life in Lung Cancer Patients Undergoing Chemotherapy |
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| Authors: | Reza Aditya Mahendra, Suryanti Dwi Pratiwi, Teguh Rahayu Sartono, Sastia Rakhma, Nanik Setijowati |
| Source: | Jurnal Respirasi, Vol 11, Iss 1, Pp 31-38 (2025) |
| Publisher Information: | Universitas Airlangga, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Medicine |
| Subject Terms: | cancer, ifn-γ, lung cancer, nigella sativa, quality of life, Medicine |
| More Details: | Introduction: In vitro and animal model studies have shown that Nigella sativa reduces cancer cell proliferation and improves chemotherapy effectiveness. Cellular activation triggers the production of IFN-γ by natural killer (NK) cells. This study examined the effect of Nigella sativa supplementation on IFN-γ levels and quality of life in lung cancer patients before and after interferon therapy. Methods: This study used a non-equivalent control experimental design involving 21 lung cancer patients undergoing initial chemotherapy at Dr. Saiful Anwar General Hospital, Malang, in 2023. The patients were divided into two groups: one group received standard chemotherapy, and another group received a combination of chemotherapy and Nigella sativa supplementation at a dose of 2x500 mg for nine weeks. The effects of this intervention were assessed by measuring IFN-γ levels using an enzyme-linked immunosorbent assay (ELISA) kit and evaluating quality of life using the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life (QLQ-C30) questionnaire before and after the fourth cycle of chemotherapy. Results: The results showed a significant increase in IFN-γ levels in the combination group undergoing chemotherapy and receiving Nigella sativa supplementation (6140.44±2233.89) compared to the standard chemotherapy group (3827.08±1722.79), with a p-value of 0.015. Quality of life improved in both groups, with scores of 53.70±6.05 before and 65.74±14.70 after chemotherapy (p=0.000). Conclusion: This study found that Nigella sativa supplementation can enhance IFN-γ levels and quality of life in lung cancer patients after four chemotherapy treatment cycles. These findings indicated that Nigella sativa could be a beneficial supplement for lung cancer patients. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2407-0831 2621-8372 |
| Relation: | https://e-journal.unair.ac.id/JR/article/view/64795; https://doaj.org/toc/2407-0831; https://doaj.org/toc/2621-8372 |
| DOI: | 10.20473/jr.v11-I.1.2025.31-38 |
| Access URL: | https://doaj.org/article/beecfcd31fda47e48fefda3087396205 |
| Accession Number: | edsdoj.beecfcd31fda47e48fefda3087396205 |
| Database: | Directory of Open Access Journals |
| ISSN: | 24070831 26218372 |
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| DOI: | 10.20473/jr.v11-I.1.2025.31-38 |
| Published in: | Jurnal Respirasi |
| Language: | English |