The effect of isolated probiotics from Indonesian Passiflora edulis sims. on interferon gamma levels in peripheral blood mononuclear cell of adult tuberculosis patients in vitro
| Title: | The effect of isolated probiotics from Indonesian Passiflora edulis sims. on interferon gamma levels in peripheral blood mononuclear cell of adult tuberculosis patients in vitro |
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| Authors: | Iif H. Nurrosyidah, Ni M. Mertaniasih, Isnaeni Isnaeni |
| Source: | Journal of Public Health in Africa, Vol 14, Iss 1 (2023) |
| Publisher Information: | AOSIS, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Public aspects of medicine |
| Subject Terms: | interferon gamma, passiflora edulis sims, probiotic, pbmc, red passion fruit, tuberculosis, Public aspects of medicine, RA1-1270 |
| More Details: | Background: Mycobacterium tuberculosis (M.tb) is unique because the bacteria live intracellularly and hide in macrophages so that they can escape from phagocytosis. This is one of the factors that complicate the treatment of M.tb infections. Interferon-gamma (IFN-γ) is a compound that plays an important role in macrophage activation to control intracellular pathogens. Objective: The purpose of this research is to analyze the concentration of IFN-γ in peripheral blood mononuclear cells of adult Tuberculosis patients (TB) after in vitro administration of multistrain probiotics from indigeneous Indonesian red passion fruit (Passiflora edulis Sims.). Method: The probiotics isolated from red passion fruit were introduced into Peripheral Blood Mononuclear Cell (PBMC) adult TB patients who were undergoing Anti-tuberculosis Drug Therapy (ATD) category one at the Trosobo Primary Health Center (Sidoarjo, East Java, Indonesia), and the patients who were undergoing ATD category one treatment were willing to be involved in this study. Result: The probiotics isolated from fermentation-broth of Indonesian red passion fruit were able to increase IFN-γ levels in PBMC of adult TB patients. Conclusion: The red passion fruit probiotics isolated can increase IFN-γ of adult TB patients increased from 0.82% to 23.17% after in vitro administration. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2038-9922 2038-9930 |
| Relation: | https://publichealthinafrica.org/index.php/jphia/article/view/98; https://doaj.org/toc/2038-9922; https://doaj.org/toc/2038-9930 |
| DOI: | 10.4081/jphia.2023.2504 |
| Access URL: | https://doaj.org/article/acbee1bf27b24ea09d4c4b7e9c336d2d |
| Accession Number: | edsdoj.bee1bf27b24ea09d4c4b7e9c336d2d |
| Database: | Directory of Open Access Journals |
| ISSN: | 20389922 20389930 |
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| DOI: | 10.4081/jphia.2023.2504 |
| Published in: | Journal of Public Health in Africa |
| Language: | English |