Academic Journal
Effect of Inferior Vena Cava Tumor Thrombus on Overall Survival in Metastatic Renal Cell Carcinoma Patients Treated with Cytoreductive Nephrectomy
| Title: | Effect of Inferior Vena Cava Tumor Thrombus on Overall Survival in Metastatic Renal Cell Carcinoma Patients Treated with Cytoreductive Nephrectomy |
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| Authors: | Benedikt Hoeh, Rocco Simone Flammia, Lukas Hohenhorst, Gabriele Sorce, Andrea Panunzio, Stefano Tappero, Zhe Tian, Fred Saad, Michele Gallucci, Alberto Briganti, Carlo Terrone, Shahrokh F. Shariat, Markus Graefen, Derya Tilki, Alessandro Antonelli, Marina Kosiba, Philipp Mandel, Luis A. Kluth, Andreas Becker, Felix K.H. Chun, Pierre I. Karakiewicz |
| Source: | European Urology Open Science, Vol 44, Iss , Pp 94-101 (2022) |
| Publisher Information: | Elsevier, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Diseases of the genitourinary system. Urology LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | Metastatic renal cell carcinoma, Cytoreductive nephrectomy, Inferior vena cava thrombus, Renal vein thrombus, Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Background: Survival data regarding cytoreductive nephrectomy (CN) in metastatic renal cell carcinoma (mRCC) patients according to the type and extent of tumor-associated vascular thrombus are scarce. Objective: To test for survival differences in mRCC patients treated with CN according to the type and extent of tumor-associated vascular thrombus. Design, setting, and participants: Within Surveillance, Epidemiology, and End Results Research Plus (2004–2017), we identified CN mRCC patients with renal vein (pT3a-TT) versus infradiaphragmatic inferior vena cava (IVC; pT3b) versus supradiaphragmatic IVC tumor thrombus/IVC invasion (pT3c). Outcome measurements and statistical analysis: Overall survival (OS) was addressed in Kaplan-Meier and Cox regression analyses, in addition to 3-mo landmark analyses. Results and limitations: Of 2170 mRCC patients, 1880 (87%), 204 (9%), and 86 (4%) harbored pT3a-TT, pT3b, and pT3c, respectively. The respective median OS periods were 21, 23, and 12 mo (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2666-1683 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S266616832200876X; https://doaj.org/toc/2666-1683 |
| DOI: | 10.1016/j.euros.2022.08.011 |
| Access URL: | https://doaj.org/article/bed1421e61804985ae8feda55f489758 |
| Accession Number: | edsdoj.bed1421e61804985ae8feda55f489758 |
| Database: | Directory of Open Access Journals |
| ISSN: | 26661683 |
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| DOI: | 10.1016/j.euros.2022.08.011 |
| Published in: | European Urology Open Science |
| Language: | English |