Bibliographic Details
| Title: |
Spatial localization of cathepsins: Implications in immune activation and resolution during infections |
| Authors: |
Elsa Anes, David Pires, Manoj Mandal, José Miguel Azevedo-Pereira |
| Source: |
Frontiers in Immunology, Vol 13 (2022) |
| Publisher Information: |
Frontiers Media S.A., 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
cathepsins, infection, inflammation, innate immunity, adaptive immunity, immune resolution, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
Cathepsins were first described, as endolysosomal proteolytic enzymes in reference to the organelles where they degrade the bulk of endogenous and exogenous substrates in a slightly acidic environment. These substrates include pathogens internalized via endocytosis and/or marked for destruction by autophagy. However, the role of cathepsins during infection far exceeds that of direct digestion of the pathogen. Cathepsins have been extensively investigated in the context of tumour associated immune cells and chronic inflammation. Several cathepsin-dependent immune responses develop in the endocytic pathway while others take place in the cytosol, the nucleus, or in the extracellular space. In this review we highlight the spatial localization of cathepsins and their implications in immune activation and resolution pathways during infection. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2022.955407/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2022.955407 |
| Access URL: |
https://doaj.org/article/be8c1c915c8144ddac1aadf716b4b5af |
| Accession Number: |
edsdoj.be8c1c915c8144ddac1aadf716b4b5af |
| Database: |
Directory of Open Access Journals |
