Bibliographic Details
| Title: |
Antiproliferation- and Apoptosis-Inducible Effects of a Novel Nitrated [6,6,6]Tricycle Derivative (SK2) on Oral Cancer Cells |
| Authors: |
Sheng-Chieh Wang, Meng-Yang Chang, Jun-Ping Shiau, Ammad Ahmad Farooqi, Yu-Hsiang Huang, Jen-Yang Tang, Hsueh-Wei Chang |
| Source: |
Molecules, Vol 27, Iss 5, p 1576 (2022) |
| Publisher Information: |
MDPI AG, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Organic chemistry |
| Subject Terms: |
nitrated [6,6,6]tricycles, apoptosis, DNA damage, antiproliferation, oral cancer, Organic chemistry, QD241-441 |
| More Details: |
The benzo-fused dioxabicyclo[3.3.1]nonane core is the central framework in several natural products. Using this core, we had developed a novel nitrated [6,6,6]tricycle-derived compound containing an n-butyloxy group, namely, SK2. The anticancer potential of SK2 was not assessed. This study aimed to determine the antiproliferative function and investigated possible mechanisms of SK2 acting on oral cancer cells. SK2 preferentially killed oral cancer cells but caused no harmful effect on non-malignant oral cells. After the SK2 exposure of oral cancer cells, cells in the sub-G1 phase accumulated. This apoptosis-like outcome of SK2 treatment was validated to be apoptosis via observing an increasing annexin V population. Mechanistically, apoptosis signalers such as pancaspase, caspases 8, caspase 9, and caspase 3 were activated by SK2 in oral cancer cells. SK2 induced oxidative-stress-associated changes. Furthermore, SK2 caused DNA damage (γH2AX and 8-hydroxy-2′-deoxyguanosine). In conclusion, a novel nitrated [6,6,6]tricycle-derived compound, SK2, exhibits a preferential antiproliferative effect on oral cancer cells, accompanied by apoptosis, oxidative stress, and DNA damage. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1420-3049 |
| Relation: |
https://www.mdpi.com/1420-3049/27/5/1576; https://doaj.org/toc/1420-3049 |
| DOI: |
10.3390/molecules27051576 |
| Access URL: |
https://doaj.org/article/be4e13ed24b64a8283a6a2daa584e8f0 |
| Accession Number: |
edsdoj.be4e13ed24b64a8283a6a2daa584e8f0 |
| Database: |
Directory of Open Access Journals |
|
Full text is not displayed to guests. |
Login for full access.
|
