Academic Journal
Resting-state oscillations reveal disturbed excitation–inhibition ratio in Alzheimer’s disease patients
| Title: | Resting-state oscillations reveal disturbed excitation–inhibition ratio in Alzheimer’s disease patients |
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| Authors: | Anne M. van Nifterick, Danique Mulder, Denise J. Duineveld, Marina Diachenko, Philip Scheltens, Cornelis J. Stam, Ronald E. van Kesteren, Klaus Linkenkaer-Hansen, Arjan Hillebrand, Alida A. Gouw |
| Source: | Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023) |
| Publisher Information: | Nature Portfolio, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | Abstract An early disruption of neuronal excitation–inhibition (E–I) balance in preclinical animal models of Alzheimer’s disease (AD) has been frequently reported, but is difficult to measure directly and non-invasively in humans. Here, we examined known and novel neurophysiological measures sensitive to E–I in patients across the AD continuum. Resting-state magnetoencephalography (MEG) data of 86 amyloid-biomarker-confirmed subjects across the AD continuum (17 patients diagnosed with subjective cognitive decline, 18 with mild cognitive impairment (MCI) and 51 with dementia due to probable AD (AD dementia)), 46 healthy elderly and 20 young control subjects were reconstructed to source-space. E–I balance was investigated by detrended fluctuation analysis (DFA), a functional E/I (fE/I) algorithm, and the aperiodic exponent of the power spectrum. We found a disrupted E–I ratio in AD dementia patients specifically, by a lower DFA, and a shift towards higher excitation, by a higher fE/I and a lower aperiodic exponent. Healthy subjects showed lower fE/I ratios ( |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 48542938 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-023-33973-8 |
| Access URL: | https://doaj.org/article/be3f5099a4854293838d27dbf4189468 |
| Accession Number: | edsdoj.be3f5099a4854293838d27dbf4189468 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 48542938 |
|---|---|
| DOI: | 10.1038/s41598-023-33973-8 |
| Published in: | Scientific Reports |
| Language: | English |