Bibliographic Details
| Title: |
Comparison of Mid-Term Prognosis in Intermediate-to-Low-Risk Contemporary Population with Guidelines-Oriented Age Cutoff |
| Authors: |
Stefano Benenati, Francesco Gallo, Won-keun Kim, Arif A. Khokhar, Tobias Zeus, Stefan Toggweiler, Roberto Galea, Federico De Marco, Antonio Mangieri, Damiano Regazzoli, Bernhard Reimers, Luis Nombela-Franco, Marco Barbanti, Ander Regueiro, Tommaso Piva, Josep Rodes-Cabau, Italo Porto, Antonio Colombo, Francesco Giannini, Alessandro Sticchi |
| Source: |
Journal of Cardiovascular Development and Disease, Vol 11, Iss 1, p 33 (2024) |
| Publisher Information: |
MDPI AG, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
aortic stenosis, transcatheter aortic valve replacement, age, surgical risk, low–intermediate risk, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
Background: Current European guidelines support transcatheter aortic valve implantation (TAVI) in intermediate-to-low-risk patients ≥75 years-old, but its prognostic relevance is unknown. Methods: Intermediate-to-low-risk (The Society of Thoracic Surgeons score p = 0.925). At Cox regression analysis, age did not predict the occurrence of all-cause death, neither as a continuous variable (HR 1.01, 95% CI 0.99–1.04, p = 0.294) nor dichotomizing according to the prespecified cutoff of 75 years (HR 0.97, 95% CI 0.63–1.51, p = 0.924). Time-to-event ROC curves showed low accuracy of age to predict all-cause mortality (area under the curve of 0.54 for both 1-year and 2-year outcomes). Conclusions: TAVI has comparable benefits across age strata for intermediate-to-low-risk patients. The age cutoff suggested by the current guidelines is not predictive of the risk of adverse events during hospital stays or of all-cause mortality through a mid-term follow-up. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2308-3425 |
| Relation: |
https://www.mdpi.com/2308-3425/11/1/33; https://doaj.org/toc/2308-3425 |
| DOI: |
10.3390/jcdd11010033 |
| Access URL: |
https://doaj.org/article/abdaf001cdc7407a99fbe7f339debdae |
| Accession Number: |
edsdoj.bdaf001cdc7407a99fbe7f339debdae |
| Database: |
Directory of Open Access Journals |
