Academic Journal
MiR-19-loaded oxidative stress-relief microgels with immunomodulatory and regeneration functions to reduce cardiac remodeling after myocardial infarction
| Title: | MiR-19-loaded oxidative stress-relief microgels with immunomodulatory and regeneration functions to reduce cardiac remodeling after myocardial infarction |
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| Authors: | Kai Wang, Jun Wen, Wen-Yao Wang, Kefei Zhao, Tong Zhou, Shunqin Wang, Qiaoxuan Wang, Liyin Shen, Yanxin Xiang, Tanchen Ren, Jinghai Chen, Yi-Da Tang, Yang Zhu, Changyou Gao |
| Source: | Bioactive Materials, Vol 48, Iss , Pp 43-54 (2025) |
| Publisher Information: | KeAi Communications Co., Ltd., 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Materials of engineering and construction. Mechanics of materials LCC:Biology (General) |
| Subject Terms: | Microgels, Cardiomyocyte regeneration, Myocardial infarction, microRNA, Inflammation, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5 |
| More Details: | Regeneration therapeutic strategy by microRNAs for boosting cardiomyocyte proliferation in treating myocardial infarction (MI) has the challenges of efficient delivery, and toxicity and risk of sudden death. Herein, oxidative stress-relief microgels were developed for miR-19a/b delivery, modulation of inflammatory tissue microenvironment, promotion of cardiomyocyte proliferation, and maintenance of heart function post MI. The cholesterol-modified miR-19a/b was encapsulated into the cavity of β-cyclodextrin in selenoketal-containing microgels. The microgels could effectively scavenge typical reactive oxygen species (ROS), and down-regulate the intracellular ROS level and the levels of typical inflammatory factors. The microgels could improve the acute inflammatory microenvironment for better cardiomyocyte survival and cellular uptake of miR-19a/b, leading to significant promotion of cardiomyocyte proliferation in vivo. In the rat and minipig models of MI, the microgels most effectively inhibited the acute inflammatory response and reduced the cardiomyocytes apoptosis, resulting in a significant improvement of cardiac function and restriction of pathological remodeling post MI, and thereby best heart function revealed by echocardiography and histological analysis. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2452-199X |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2452199X25000520; https://doaj.org/toc/2452-199X |
| DOI: | 10.1016/j.bioactmat.2025.02.004 |
| Access URL: | https://doaj.org/article/cebd9265d7724a518683dbec5bdcfd13 |
| Accession Number: | edsdoj.bd9265d7724a518683dbec5bdcfd13 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2452199X |
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| DOI: | 10.1016/j.bioactmat.2025.02.004 |
| Published in: | Bioactive Materials |
| Language: | English |