Dose adjustment of follicle-stimulating hormone (FSH) during ovarian stimulation as part of medically-assisted reproduction in clinical studies: a systematic review covering 10 years (2007–2017)

Bibliographic Details
Title:	Dose adjustment of follicle-stimulating hormone (FSH) during ovarian stimulation as part of medically-assisted reproduction in clinical studies: a systematic review covering 10 years (2007–2017)
Authors:	Human Fatemi, Wilma Bilger, Deborah Denis, Georg Griesinger, Antonio La Marca, Salvatore Longobardi, Mary Mahony, Xiaoyan Yin, Thomas D’Hooghe
Source:	Reproductive Biology and Endocrinology, Vol 19, Iss 1, Pp 1-15 (2021)
Publisher Information:	BMC, 2021.
Publication Year:	2021
Collection:	LCC:Gynecology and obstetrics LCC:Reproduction
Subject Terms:	Follicle-stimulating hormone (FSH), FSH dose adjustment, Recombinant-human FSH, Follitropin, Controlled ovarian stimulation (COS), In vitro fertilization (IVF), Gynecology and obstetrics, RG1-991, Reproduction, QH471-489
More Details:	Abstract Background Individualization of the follicle-stimulating hormone (FSH) starting dose is considered standard clinical practice during controlled ovarian stimulation (COS) in patients undergoing assisted reproductive technology (ART) treatment. Furthermore, the gonadotropin dose is regularly adjusted during COS to avoid hyper- or hypo-ovarian response, but limited data are currently available to characterize such adjustments. This review describes the frequency and direction (increase/decrease) of recombinant-human FSH (r-hFSH) dose adjustment reported in clinical trials. Methods We evaluated the proportion of patients undergoing ART treatment who received ≥ 1 r-hFSH dose adjustments. The inclusion criteria included studies (published Sept 2007 to Sept 2017) in women receiving ART treatment that allowed dose adjustment within the study protocol and that reported ≥ 1 dose adjustments of r-hFSH; studies not allowing/reporting dose adjustment were excluded. Data on study design, dose adjustment and patient characteristics were extracted. Point-incidence estimates were calculated per study and overall based on pooled number of cycles with dose adjustment across studies. The Clopper–Pearson method was used to calculate 95% confidence intervals (CI) for incidence where adjustment occurred in
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1477-7827
Relation:	https://doaj.org/toc/1477-7827
DOI:	10.1186/s12958-021-00744-x
Access URL:	https://doaj.org/article/ebcb4dd4efc94be981e96936dd186b1c
Accession Number:	edsdoj.bcb4dd4efc94be981e96936dd186b1c
Database:	Directory of Open Access Journals
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More Details
ISSN:	14777827
DOI:	10.1186/s12958-021-00744-x
Published in:	Reproductive Biology and Endocrinology
Language:	English