Bibliographic Details
| Title: |
Clinical significance of FBXO17 gene expression in high-grade glioma |
| Authors: |
Di Du, Jian Yuan, Wencai Ma, Jing Ning, John N. Weinstein, Xianrui Yuan, Greg N. Fuller, Yuexin Liu |
| Source: |
BMC Cancer, Vol 18, Iss 1, Pp 1-10 (2018) |
| Publisher Information: |
BMC, 2018. |
| Publication Year: |
2018 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
FBXO17, High-grade glioma, Gene expression, Epigenetics, Prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Abstract Background High-grade gliomas (HGGs) exhibit marked heterogeneity in clinical behavior. The purpose of this study was to identify a novel biomarker that predicts patient outcome, which is helpful in HGG patient management. Methods We analyzed gene expression profiles of 833 HGG cases, representing the largest patient population ever reported. Using the data set from the Cancer Genome Atlas (TCGA) and random partitioning approach, we performed Cox proportional hazards model analysis to identify novel prognostic mRNAs in HGG. The predictive capability was further assessed via multivariate analysis and validated in 4 additional data sets. The Kaplan-Meier method was used to evaluate survival difference between dichotomic groups of patients. Correlation of gene expression and DNA methylation was evaluated via Student’s t-test. Results Patients with elevated FBXO17 expression had a significantly shorter overall survival (OS) (P = 0.0011). After adjustment by IDH1 mutation, sex, and patient age, FBXO17 gene expression was significantly associated with OS (HR = 1.29, 95% CI =1.04–1.59, P = 0.018). In addition, FBXO17 expression can significantly distinguish patients by OS not only among patients who received temozolomide chemotherapy (HR 1.35, 95% CI =1.12–1.64, P = 0.002) but also among those who did not (HR = 1.48, 95% CI =1.20–1.82, P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2407 |
| Relation: |
http://link.springer.com/article/10.1186/s12885-018-4680-3; https://doaj.org/toc/1471-2407 |
| DOI: |
10.1186/s12885-018-4680-3 |
| Access URL: |
https://doaj.org/article/bc6ae5be7e0f49b58d1c45d60c5b797f |
| Accession Number: |
edsdoj.bc6ae5be7e0f49b58d1c45d60c5b797f |
| Database: |
Directory of Open Access Journals |
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