The Waveform Fluctuation and the Clinical Factors of the Initial and Sustained Erythropoietic Response to Continuous Erythropoietin Receptor Activator in Hemodialysis Patients
| Title: | The Waveform Fluctuation and the Clinical Factors of the Initial and Sustained Erythropoietic Response to Continuous Erythropoietin Receptor Activator in Hemodialysis Patients |
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| Authors: | Wen-Sheng Liu, Yueh-Lin Wu, Szu-Yuan Li, Wu-Chang Yang, Tzen-Wen Chen, Chih-Ching Lin |
| Source: | The Scientific World Journal, Vol 2012 (2012) |
| Publisher Information: | Hindawi Limited, 2012. |
| Publication Year: | 2012 |
| Collection: | LCC:Technology LCC:Medicine LCC:Science |
| Subject Terms: | Technology, Medicine, Science |
| More Details: | Objectives. Erythropoiesis-stimulating agents (ESA) are the main treatment for anemia in hemodialysis (HD) patients. We evaluated factors determining the response after treatment of a new ESA (continuous erythropoietin erythropoietin receptor activator (CERA)). Methods. 61 HD patients were classified by their response at two different timings. First, patients whose hematocrit (Hct) increased 1.5% in the first week were defined as initial responders (IR, n=16). We compared several parameters between IR and the rest of the study subjects (non-IR, n=45). Second, patients whose Hct increased 2% in the 4th week were defined as sustained responders (SR, n=12), and we did a similar comparison. Results. The Hct showed a waveform fluctuation. Compared with the rest, IR had significantly lower platelet counts and higher levels of ferritin, total protein, total bilirubin, and serum sodium, while SR had significantly lower levels of C-reactive protein and low-density lipoprotein (All P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1537-744X |
| Relation: | https://doaj.org/toc/1537-744X |
| DOI: | 10.1100/2012/157437 |
| Access URL: | https://doaj.org/article/bc6a44296c3941fcb3963f621bf9df3a |
| Accession Number: | edsdoj.bc6a44296c3941fcb3963f621bf9df3a |
| Database: | Directory of Open Access Journals |
| ISSN: | 1537744X |
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| DOI: | 10.1100/2012/157437 |
| Published in: | The Scientific World Journal |
| Language: | English |