Seasonal variation in serum metabolites of northern European dogs
| Title: | Seasonal variation in serum metabolites of northern European dogs |
|---|---|
| Authors: | Hannah K. Walker, Claudia Ottka, Hannes Lohi, Ian Handel, Dylan N. Clements, Adam G. Gow, Richard J. Mellanby |
| Source: | Journal of Veterinary Internal Medicine, Vol 36, Iss 1, Pp 190-195 (2022) |
| Publisher Information: | Wiley, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Veterinary medicine |
| Subject Terms: | canine, cholesterol, lactate, lipid, metabolomics, Veterinary medicine, SF600-1100 |
| More Details: | Abstract Background Metabolic profiling identifies seasonal variance of serum metabolites in humans. Despite the presence of seasonal disease patterns, no studies have assessed whether serum metabolites vary seasonally in dogs. Hypothesis There is seasonal variation in the serum metabolite profiles of healthy dogs. Animals Eighteen healthy, client‐owned dogs. Methods A prospective cohort study. Serum metabolomic profiles were assessed monthly in 18 healthy dogs over a 12‐month period. Metabolic profiling was conducted using a canine‐specific proton nuclear magnetic resonance spectroscopy platform, and the effects of seasonality were studied for 98 metabolites using a cosinor model. Seasonal component was calculated, which describes the seasonal variation of each metabolite. Results We found no evidence of seasonal variation in 93 of 98 metabolites. Six metabolites had statistically significant seasonal variance, including cholesterol (mean 249 mg/dL [6.47 mmol/L] with a seasonal component amplitude of 9 mg/dL [0.23 mmol/L]; 95% confidence interval [CI] 6‐13 mg/dL [0.14‐0.33 mmol/L], P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1939-1676 0891-6640 |
| Relation: | https://doaj.org/toc/0891-6640; https://doaj.org/toc/1939-1676 |
| DOI: | 10.1111/jvim.16298 |
| Access URL: | https://doaj.org/article/bc65e65de4784c3e96d197e1177a7c87 |
| Accession Number: | edsdoj.bc65e65de4784c3e96d197e1177a7c87 |
| Database: | Directory of Open Access Journals |
| ISSN: | 19391676 08916640 |
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| DOI: | 10.1111/jvim.16298 |
| Published in: | Journal of Veterinary Internal Medicine |
| Language: | English |