Bibliographic Details
| Title: |
Association of fish oil containing lipid emulsions with retinopathy of prematurity: a retrospective observational study |
| Authors: |
Rongqiang Yang, Hao Ding, Jing Shan, Xiaole Li, Jian Zhang, Guanghui Liu, Hong Zheng, Yu Su, Hongyang Yao, Kemin Qi |
| Source: |
BMC Pediatrics, Vol 22, Iss 1, Pp 1-7 (2022) |
| Publisher Information: |
BMC, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Pediatrics |
| Subject Terms: |
Retinopathy of prematurity, n-3 polyunsaturated fatty acids, Preterm infants, Fish oil, Lipid emulsions, Pediatrics, RJ1-570 |
| More Details: |
Abstract Background Retinopathy of prematurity (ROP) remains a leading cause of childhood blindness worldwide. This study aimed to investigate whether supplementation of n-3 polyunsaturated fatty acids (n-3 PUFAs) in parenteral nutrition may have beneficial effects on ROP in preterm infants. Methods A total of 89 preterm infants, admitted to Neonatal Intensive Care Unit (NICU) in Anhui Provincial Children’s Hospital from September 2017 to August 2020, were recruited in the study. Based on the medical documents, the subjects were categorised into two groups: administration of the fish oil emulsion (n=43) containing soy oil, medium-chain-triglycerides (MCT), olive oil and fish oil (6g/dL, 6g/dL, 5g/dL and 3g/dL respectively), and the soy oil emulsion (n=46) containing 10g/dL of soy oil and MCT each. At 4 weeks of hospitalization, ROP was screened and diagnosed. Fatty acids in erythrocytes were determined using gas chromatography. Results The averaged birth weight and gestational age were 1594±296 g and 31.9±2.3 wk, 1596±263 g and 31.6±2.3 wk respectively for preterm infants in the fish oil group and soy oil group. After 4 to 6 weeks of hospitalization, among all the preterm infants, 52 developed ROP (all stages) indicating an incidence of ROP at 58.43%. Although the incidence of ROP with any stages showed no differences between the two groups, the severe ROP incidence in the group with fish oil emulsions (2.33%) was significantly lower than that in the group with soy oil emulsions (23.91%) (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2431 |
| Relation: |
https://doaj.org/toc/1471-2431 |
| DOI: |
10.1186/s12887-022-03174-9 |
| Access URL: |
https://doaj.org/article/bc561715ffca4c20949d4ba9b6fedb29 |
| Accession Number: |
edsdoj.bc561715ffca4c20949d4ba9b6fedb29 |
| Database: |
Directory of Open Access Journals |
