Are sodium-glucose co-transporter-2 inhibitors associated with improved outcomes in diabetic patients admitted to intensive care units with septic shock?
| Title: | Are sodium-glucose co-transporter-2 inhibitors associated with improved outcomes in diabetic patients admitted to intensive care units with septic shock? |
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| Authors: | Nikita Ashcherkin, Abdelmohaymin A. Abdalla, Simran Gupta, Shubhang Bhatt, Claire I. Yee, Rodrigo Cartin-Ceba |
| Source: | Acute and Critical Care, Vol 39, Iss 2, Pp 251-256 (2024) |
| Publisher Information: | Korean Society of Critical Care Medicine, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medical emergencies. Critical care. Intensive care. First aid |
| Subject Terms: | intensive care unit, mortality, septic shock, sodium-glucose cotransporter-2 inhibitor, type 2 diabetes mellitus, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9 |
| More Details: | Background Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have been shown to reduce organ dysfunction in renal and cardiovascular disease. There are limited data on the role of SGLT2i in acute organ dysfunction. We conducted a study to assess the effect of SGLT2i taken prior to intensive care unit (ICU) admission in diabetic patients admitted with septic shock. Methods This retrospective cohort study used electronic medical records and included diabetic patients admitted to the ICU with septic shock. We compared diabetic patients on SGLT2i to those who were not on SGLT2i prior to admission. The primary outcome was in-hospital mortality, and secondary outcomes included hospital and ICU length of stay, use of renal replacement therapy, and 28- and 90-day mortality. Results A total of 98 diabetic patients was included in the study, 36 in the SGLT2i group and 62 in the non-SGLT2i group. The Sequential Organ Failure Assessment and Acute Physiology and Chronic Health Evaluation III scores were similar in the groups. Inpatient mortality was significantly lower in the SGLT2i group (5.6% vs. 27.4%, P=0.008). There was no significant difference in secondary outcomes. Conclusion Our study found that diabetic patients on SGLT2i prior to hospitalization who were admitted to the ICU with septic shock had lower inpatient mortality compared to patients not on SGLT2i. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2586-6052 2586-6060 |
| Relation: | http://www.accjournal.org/upload/pdf/acc-2023-01046.pdf; https://doaj.org/toc/2586-6052; https://doaj.org/toc/2586-6060 |
| DOI: | 10.4266/acc.2023.01046 |
| Access URL: | https://doaj.org/article/bc5127fe20734e92b7a0344b914d3613 |
| Accession Number: | edsdoj.bc5127fe20734e92b7a0344b914d3613 |
| Database: | Directory of Open Access Journals |
| ISSN: | 25866052 25866060 |
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| DOI: | 10.4266/acc.2023.01046 |
| Published in: | Acute and Critical Care |
| Language: | English |