Bibliographic Details
| Title: |
Right ventricular diastolic adaptation to pressure overload in different rat strains |
| Authors: |
Julie S. Axelsen, Stine Andersen, Steffen Ringgaard, Rowan Smal, Aida Lluciá‐Valldeperas, Jens Erik Nielsen‐Kudsk, Frances S. deMan, Asger Andersen |
| Source: |
Physiological Reports, Vol 12, Iss 13, Pp n/a-n/a (2024) |
| Publisher Information: |
Wiley, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Physiology |
| Subject Terms: |
diastolic dysfunction, pulmonary trunk banding, rat strains, right ventricular failure, Physiology, QP1-981 |
| More Details: |
Abstract Different rat strains are used in various animal models of pulmonary hypertension and right ventricular (RV) failure. No systematic assessment has been made to test differences in RV response to pressure overload between rat strains. We compared RV adaptation to pulmonary trunk banding (PTB) in Wistar (W), Sprague Dawley (SD), and Fischer344 (F) rats by hemodynamic profiling focusing on diastolic function. Age‐matched male rat weanlings were randomized to sham surgery (W‐sham, n = 5; SD‐sham, n = 4; F‐sham, n = 4) or PTB (W‐PTB, n = 8; SD‐PTB, n = 8; F‐PTB, n = 8). RV function was evaluated after 5 weeks by echocardiography, cardiac MRI, and invasive pressure‐volume measurements. PTB caused RV failure and increased RV systolic pressures four‐fold in all three PTB groups compared with sham. W‐ and SD‐PTB had a 2.4‐fold increase in RV end‐systolic volume index compared with sham, while F‐PTB rats were less affected. Diastolic and right atrial impairment were evident by increased RV end‐diastolic elastance, filling pressure, and E/e' in PTB rats compared with sham, again F‐PTB the least affected. In conclusions, PTB caused RV failure with signs of diastolic dysfunction. Despite a similar increase in RV systolic pressure, F‐PTB rats showed less RV dilatation and a more preserved diastolic function compared with W‐ and SD‐PTB. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2051-817X |
| Relation: |
https://doaj.org/toc/2051-817X |
| DOI: |
10.14814/phy2.16132 |
| Access URL: |
https://doaj.org/article/bb55993abf7c4ffabf2de252125f3bed |
| Accession Number: |
edsdoj.bb55993abf7c4ffabf2de252125f3bed |
| Database: |
Directory of Open Access Journals |
