Bibliographic Details
| Title: |
Gut microbiota changes after metabolic surgery in adult diabetic patients with mild obesity: a randomised controlled trial |
| Authors: |
Eva Lau, Eugeni Belda, Paul Picq, Davide Carvalho, Manuel Ferreira-Magalhães, Maria Manuel Silva, Isaac Barroso, Flora Correia, Cidália Pina Vaz, Isabel Miranda, Adelino Barbosa, Karine Clément, Joel Doré, Paula Freitas, Edi Prifti |
| Source: |
Diabetology & Metabolic Syndrome, Vol 13, Iss 1, Pp 1-15 (2021) |
| Publisher Information: |
BMC, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Nutritional diseases. Deficiency diseases |
| Subject Terms: |
Diabetes mellitus, Insulin resistance, Microbiome, Roux-en-Y gastric bypass, Weight loss, Nutritional diseases. Deficiency diseases, RC620-627 |
| More Details: |
Abstract Background Roux-en-Y gastric bypass (RYGB) surgery is one of the most efficient procedures for the treatment of obesity, also improving metabolic and inflammatory status, in patients with mild obesity. The underlying mechanisms have not been fully understood, but gut microbiota is hypothesized to play a key role. Our aim was to evaluate the association between gut microbiota changes and anthropometric, metabolic and inflammatory profiles after metabolic surgery compared with medical therapy, in type 2 diabetic (T2DM) adults with mild obesity (BMI 30–35 kg/m2). Methods DM2 was an open-label, randomised controlled clinical trial (RCT: ISRCTN53984585) with 2 arms: (i) surgical, and (ii) medical. The main outcome was gut microbiota changes after: metabolic surgery (Roux-en-Y gastric bypass—RYGB) versus standard medical therapy. Secondary outcomes included anthropometric, metabolic and inflammatory profiles. Clinical visits, blood workup, and stool samples were collected at baseline and months (M)1, 3, 6, 12. Gut microbiota was profiled using 16S rRNA targeted sequencing. Results Twenty patients were included: 10 in surgical and 10 in medical arm. Anthropometric and metabolic comparative analysis favoured RYGB over medical arm. At M12, the percentage of weight loss was 25.5 vs. 4.9% (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1758-5996 |
| Relation: |
https://doaj.org/toc/1758-5996 |
| DOI: |
10.1186/s13098-021-00672-1 |
| Access URL: |
https://doaj.org/article/bb4eebebeab746c49b3c477bee9b8f27 |
| Accession Number: |
edsdoj.bb4eebebeab746c49b3c477bee9b8f27 |
| Database: |
Directory of Open Access Journals |
